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一名患有门静脉血栓形成和肝周淋巴结转移的肝细胞癌患者,在接受阿替唑单抗联合贝伐单抗治疗后接受了转化手术,实现了病理完全缓解。

A patient who underwent conversion surgery after atezolizumab plus bevacizumab for hepatocellular carcinoma with portal vein thrombosis and perihepatic lymph node metastases achieved a pathological complete response.

作者信息

Okuno Masayuki, Ohama Hideko, Nakamura Ikuo, Yoshida Makoto, Shirai Daisuke, Hirai Takahito, Fuji Hiroaki, Kurimoto Ami, Okamoto Tomohiro, Sueoka Hideaki, Iida Kenjiro, Tada Masaharu, Kihara Takako, Tanaka Hironori, Hirono Seiko

机构信息

Department of Gastroenterological Surgery, Hyogo Medical University, Nishinomiya, Japan.

Department of Surgery, Hanwa Memorial Hospital, Osaka, Japan.

出版信息

Int Cancer Conf J. 2024 May 7;13(3):306-312. doi: 10.1007/s13691-024-00683-5. eCollection 2024 Jul.

Abstract

Here, we present a patient with hepatocellular carcinoma complicated by tumor thrombosis into the main portal trunk and perihepatic lymph node metastases who was treated with atezolizumab plus bevacizumab. Shrinkage of the main tumor, portal vein thrombosis, and lymph node metastases were achieved; therefore, hepatectomy with lymphadenectomy could be performed. Final pathology indicated a complete pathological response in the main tumor, portal vein thrombosis, and perihepatic lymph nodes. The patient is currently alive with no evidence of recurrence on radiological assessment at 3 months after surgery.

摘要

在此,我们报告一例肝细胞癌患者,其合并有肿瘤血栓形成至肝门主干以及肝周淋巴结转移,接受了阿替利珠单抗联合贝伐单抗治疗。主肿瘤、门静脉血栓形成和淋巴结转移均有缩小;因此,可以进行肝切除术加淋巴结清扫术。最终病理显示主肿瘤、门静脉血栓形成和肝周淋巴结出现完全病理缓解。患者目前仍存活,术后3个月的影像学评估未发现复发迹象。

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