Stern B J, Krumholz A, Johns C, Scott P, Nissim J
Arch Neurol. 1985 Sep;42(9):909-17. doi: 10.1001/archneur.1985.04060080095022.
Neurosarcoidosis is a disorder that is difficult to diagnose and manage. We assessed its neurological manifestations in 649 patients seen at The Johns Hopkins Hospital, Baltimore, from 1975 through 1980. Neurological problems could be attributed to neurosarcoidosis in 33 patients (5.1%). The presenting manifestation of sarcoidosis was neurological in 16 (48%) of them. Cranial neuropathy was the most frequent problem, and a peripheral facial nerve palsy was the single most common abnormality. Other manifestations were aseptic meningitis, hydrocephalus, parenchymatous disease of the central nervous system, peripheral neuropathy, and myopathy. Three-quarters of the patients were treated with steroids. The outcome was good in 27 (82%) of 33 episodes of neurological dysfunction in 25 patients with a well-documented clinical course. A thorough investigation of patients with suspected neurosarcoidosis is recommended to establish the diagnosis, delineate the extent of disease, and guide therapy.
神经结节病是一种难以诊断和治疗的疾病。我们评估了1975年至1980年期间在巴尔的摩约翰霍普金斯医院就诊的649例患者的神经表现。33例患者（5.1%）的神经问题可归因于神经结节病。其中16例（48%）患者结节病的首发表现为神经症状。颅神经病变是最常见的问题，而周围性面神经麻痹是最常见的单一异常。其他表现包括无菌性脑膜炎、脑积水、中枢神经系统实质疾病、周围神经病变和肌病。四分之三的患者接受了类固醇治疗。在25例有详细记录的临床病程患者中，33次神经功能障碍发作中有27次（82%）预后良好。建议对疑似神经结节病患者进行全面检查，以明确诊断、界定疾病范围并指导治疗。
