The Affiliated Nanhua Hospital, Department of Nephrology, Hengyang Medical School, University of South China, Hunan, China.
Department of Nephropathy Rheumatism, Hainan Traditional Chinese Medicine Hospital, Hainan, China.
Asia Pac J Clin Nutr. 2024 Sep;33(3):313-318. doi: 10.6133/apjcn.202409_33(3).0003.
Proteinuria, a hallmark of renal and systemic disorders, is associated with adverse outcomes, especially in chronic kidney disease and cardiovascular disease. Omega-3 fatty acids have garnered attention for their cardiovascular benefits and potential therapeutic effects on proteinuria. This systematic review and meta-analysis aimed to evaluate the impact of omega-3 fatty acid supplementation on proteinuria levels across various kidney-related conditions.
Studies published from 1989 to 2023 were systematically identified, including randomized controlled trials, cohort, case-control, and cross-sectional studies. Nine studies involving a total of 347 participants were included in the analysis.
The meta-analysis revealed a neutral overall effect size of omega-3 fatty acid supplementation on proteinuria levels, assessed under both common and random effect models. Despite the lack of statistically significant evidence supporting the efficacy of omega-3 fatty acids in reducing proteinuria, the variability in interventions and patient populations suggests potential individual responses.
The find-ings highlight the heterogeneity in responses to omega-3 fatty acid supplementation and emphasize the need for cautious interpretation. While no definitive conclusion can be drawn, the results underscore the importance of targeted research focusing on specific subgroups or conditions that may benefit from omega-3 supplementation. These findings contribute to the evolving understanding of personalized kidney health strategies and pave the way for further exploration and optimization of omega-3 fatty acids' therapeutic applications.
蛋白尿是肾脏和全身疾病的标志，与不良结局相关，尤其是在慢性肾脏病和心血管疾病中。ω-3 脂肪酸因其对心血管的益处以及对蛋白尿的潜在治疗作用而受到关注。本系统评价和荟萃分析旨在评估 ω-3 脂肪酸补充剂对各种与肾脏相关疾病的蛋白尿水平的影响。
系统地检索了 1989 年至 2023 年发表的研究，包括随机对照试验、队列研究、病例对照研究和横断面研究。共有 9 项研究纳入了 347 名参与者进行分析。
荟萃分析显示，在常见和随机效应模型下，ω-3 脂肪酸补充剂对蛋白尿水平的总体效应大小为中性。尽管没有统计学证据支持 ω-3 脂肪酸在减少蛋白尿方面的疗效，但干预措施和患者人群的变异性表明可能存在个体反应。
研究结果突出了对 ω-3 脂肪酸补充剂反应的异质性，并强调了谨慎解释的必要性。虽然不能得出明确的结论，但这些结果强调了针对可能受益于 ω-3 补充的特定亚组或情况进行有针对性研究的重要性。这些发现有助于深入了解个性化肾脏健康策略，并为进一步探索和优化 ω-3 脂肪酸的治疗应用铺平道路。
