Noh Seungmin, Hong Hye Kyoung, Kim Dong Geun, Jeong Hwajun, Lim Sung Jun, Kim Jin-Young, Woo Se Joon, Choi Hongsoo
Department of Robotics and Mechatronics Engineering, Daegu Gyeong-buk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea.
DGIST-ETH Microrobotics Research Center, DGIST, Daegu 42988, Republic of Korea.
ACS Omega. 2024 Jun 20;9(26):27888-27897. doi: 10.1021/acsomega.3c07033. eCollection 2024 Jul 2.
Although the number of patients with eye diseases is increasing, efficient drug delivery to the posterior segment of the eyeball remains challenging. The reasons include the unique anatomy of the eyeball, the blood-aqueous barrier, the blood-retina barrier, and drug elimination via the anterior chamber and uveoscleral routes. Solutions to these obstacles for therapeutic delivery to the posterior segment will increase the efficacy, efficiency, and safety of ophthalmic treatment. Micro/nanorobots are promising tools to deliver therapeutics to the retina under the direction of an external magnetic field. Although many groups have evaluated potential uses of micro/nanorobots in retinal treatment, most experiments have been performed under idealized in vitro laboratory conditions and thus do not fully demonstrate the clinical feasibility of this approach. This study examined the use of magnetic nanoparticles (MNPs) to deliver dexamethasone, a drug widely used in retinal disease treatment. The MNPs allowed sustainable drug release and successful magnetic manipulation inside bovine vitreous humor and the vitreous humor of living rabbits. Therefore, controlled drug distribution via magnetic manipulation of MNPs is a promising strategy for targeted drug delivery to the retina.
尽管患有眼部疾病的患者数量在不断增加，但将药物有效递送至眼球后段仍然具有挑战性。原因包括眼球独特的解剖结构、血-房水屏障、血-视网膜屏障以及通过前房和葡萄膜巩膜途径的药物消除。解决这些阻碍后段治疗性给药的问题将提高眼科治疗的疗效、效率和安全性。微型/纳米机器人是在外部磁场引导下将治疗药物递送至视网膜的有前景的工具。尽管许多研究小组已经评估了微型/纳米机器人在视网膜治疗中的潜在用途，但大多数实验都是在理想化的体外实验室条件下进行的，因此不能充分证明这种方法的临床可行性。本研究考察了使用磁性纳米颗粒（MNP）递送地塞米松的情况，地塞米松是一种广泛用于视网膜疾病治疗的药物。这些磁性纳米颗粒能够实现药物的持续释放，并在牛玻璃体液和活体兔玻璃体液内成功进行磁性操控。因此，通过对磁性纳米颗粒进行磁性操控来控制药物分布是一种有前景的视网膜靶向给药策略。
