Department of Obstetrics and Gynecology, People's Hospital of Chongqing Banan District, Banan Hospital of Chongqing Medical University, Chongqing, China.
Department of Obstetrics and Gynecology, Liaocheng People's Hospital and Liaocheng Clinical School of Shandong First Medical University, Shandong, Liaocheng, China.
Gynecol Endocrinol. 2024 Dec;40(1):2375564. doi: 10.1080/09513590.2024.2375564. Epub 2024 Jul 8.
To comprehensively assess the dose-response association between dietary glycemic index (GI) and glycemic load (GL) and gestational diabetes mellitus (GDM) risk.
PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang, and VIP databases were searched up to May 29, 2024. Studies with at least three exposure categories were included. Dose-response analysis was also performed when covariates were adjusted in the included studies.
Thirteen studies involving 39,720 pregnant women were included. A linear relationship was found between GI and the risk of GDM (χ = 4.77, = .0923). However, association was not significant (χ = 0.06, = .8000). For every unit increase in GI (range 0-30), GDM risk increased by 0.29%. After adjusting for covariates, the linear relationship persisted (χ = 4.95, = .084) with no significant association (χ = 0.08, = .7775). For GL, a linear relationship was also found (χ = 4.17, =.1245), but GL was not significantly associated with GDM risk (χ = 2.63, = .1049). The risk of GDM increased by 0.63% per unit increase in GL. After covariate adjustment, a significant association was observed (χ = 6.28, = .0122).
No significant association between GI and GDM risk was found. After adjusting for covariates, GL shows a significant association with GDM risk. Our findings emphasize the importance of considering dietary GL in managing the risk of GDM. Future research should continue to explore these relationships with standardized diagnostic criteria and robust adjustment for potential confounders.
全面评估膳食血糖指数（GI）和血糖负荷（GL）与妊娠期糖尿病（GDM）风险之间的剂量-反应关系。
检索PubMed、Embase、Cochrane 图书馆、Web of Science、中国知网、万方和维普数据库，检索时间截至 2024 年 5 月 29 日。纳入至少有 3 个暴露类别的研究。在纳入的研究中，当调整协变量时，也进行了剂量-反应分析。
纳入了 13 项涉及 39720 名孕妇的研究。GI 与 GDM 风险之间存在线性关系（χ=4.77，=.0923）。然而，关联并不显著（χ=0.06，=.8000）。GI 每增加一个单位（范围 0-30），GDM 风险增加 0.29%。调整协变量后，线性关系仍然存在（χ=4.95，=.084），但关联不显著（χ=0.08，=.7775）。对于 GL，也发现了线性关系（χ=4.17，=.1245），但 GL 与 GDM 风险无显著关联（χ=2.63，=.1049）。GL 每增加一个单位，GDM 风险增加 0.63%。调整协变量后，观察到显著关联（χ=6.28，=.0122）。
GI 与 GDM 风险之间未发现显著关联。调整协变量后，GL 与 GDM 风险呈显著关联。我们的研究结果强调了在管理 GDM 风险时考虑膳食 GL 的重要性。未来的研究应继续使用标准化的诊断标准和稳健的调整方法来探索这些关系，并考虑潜在的混杂因素。
Zotero 插件