亚肺叶切除与肺叶切除治疗ⅠA 期非小细胞肺癌的生存和肺功能：一项更新的荟萃分析。
Survival and pulmonary function in stage IA non-small cell lung cancer after sublobar resection versus lobectomy: An updated meta-analysis.
机构信息
Department of Medicine, Federal University of Sao Joao del-Rei, Divinopolis, Brazil.
Department of Medicine, Pontifical Catholic University of Sao Paulo, São Paulo, Brazil.
出版信息
J Surg Oncol. 2024 Sep;130(3):523-532. doi: 10.1002/jso.27767. Epub 2024 Jul 9.
Traditionally, lobectomy was standard for stage IA non-small-cell lung cancer (NSCLC). Recent RCTs suggest sublobar resection's comparable outcomes. Our meta-analysis, incorporating 30 studies (including four RCTs), assessed sublobar resection's efficacy. Employing a random-effects model and I statistics for heterogeneity, we found sublobar resection reduced DFS (HR 1.31, p < 0.01) and OS (HR 1.27, p < 0.01) overall. However, RCT subgroup analysis showed no significant differences in DFS (p = 0.28) or OS (p = 0.62). Sublobar resection is a viable option for well-selected patients.
传统上，肺叶切除术是 IA 期非小细胞肺癌（NSCLC）的标准治疗方法。最近的 RCT 表明亚肺叶切除术的结果相当。我们的荟萃分析纳入了 30 项研究（包括 4 项 RCT），评估了亚肺叶切除术的疗效。采用随机效应模型和 I 统计量进行异质性分析，我们发现亚肺叶切除术降低了 DFS（HR 1.31，p<0.01）和 OS（HR 1.27，p<0.01）。然而，RCT 亚组分析显示 DFS（p=0.28）或 OS（p=0.62）无显著差异。对于精选的患者，亚肺叶切除术是一种可行的选择。
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