Department of Anesthesia and Critical Care Medicine, University of Chicago, Chicago, IL, United States.
Section of Cardiothoracic Surgery, University of Chicago, Chicago, IL, United States.
J Cardiothorac Vasc Anesth. 2024 Sep;38(9):2047-2058. doi: 10.1053/j.jvca.2024.03.045. Epub 2024 Apr 3.
Heart transplantation is the definitive treatment for refractory, end-stage heart failure. The number of patients awaiting transplantation far exceeds available organs. In an effort to expand the donor pool, donation after circulatory death (DCD) heart transplantation has garnered renewed interest. Unlike donation after brain death, DCD donors do not meet the criteria for brain death and are dependent on life-sustaining therapies. Procurement can include a direct strategy or a normothermic regional perfusion, whereby there is restoration of perfusion to the organ before explantation. There are new developments in cold storage and ex vivo perfusion strategies. Since its inception, there has been a steady improvement in post-transplant outcomes, largely attributed to advancements in operative and procurement strategies. In this narrative review, the authors address the unique considerations of DCD heart transplantation, including withdrawal of care, the logistics of procuring and resuscitating organs, outcomes compared with standard donation after brain death, and ethical considerations.
心脏移植是治疗难治性终末期心力衰竭的确定性方法。等待移植的患者人数远远超过可供移植的器官数量。为了扩大供体库,心脏死后循环捐献(DCD)心脏移植重新引起了人们的兴趣。与脑死亡后捐献不同,DCD 供者不符合脑死亡标准,并且依赖生命支持治疗。获取可以包括直接策略或常温区域灌注,在此过程中,在器官取出前恢复器官的灌注。在冷藏和体外灌注策略方面有新的发展。自成立以来,移植后的结果稳步改善,这在很大程度上归因于手术和获取策略的进步。在这篇叙述性评论中,作者讨论了 DCD 心脏移植的独特考虑因素,包括停止治疗、获取和复苏器官的后勤工作、与标准脑死亡后捐献相比的结果以及伦理考虑。