Diagnosing sucrase-isomaltase deficiency: a comparison of a C-sucrose breath test and a duodenal enzyme assay.

BACKGROUND

Reduced activity of the sucrase-isomaltase (SI) enzyme can cause gastrointestinal symptoms. Biochemical measurement of SI activity in small intestinal biopsies is presently considered the gold standard for the diagnosis of SI deficiency, but this invasive test is not suitable as a routine diagnostic tool.

AIM

To evaluate a C-sucrose-breath test (CSBT) as a diagnostic tool for SI deficiency in an adult population.

METHODS

CSBT results were compared to sucrase activity measured in duodenal biopsies.

RESULTS

Forty patients with gastrointestinal symptoms were included in the study, 4 of whom had celiac disease and the rest ( = 36) had normal histological findings. Nine patients (22.5%) had low sucrase activity measured using duodenal biopsies. No correlation was observed between enzymatic sucrase activity and the CSBT results. The CSBT-curves for the celiac patients versus patients with normal duodenal histology demonstrated that the patients with celiac disease were within the lower range of the distribution.

CONCLUSION

We observed a mismatch between the CSBT results and the biochemically measured sucrase activity, suggesting that SI activity is not uniformly distributed throughout the small intestines. This methodological discrepancy should be acknowledged when diagnosing SI deficiency.