睾酮在危重症患者护理中的作用综述。
A review of the role of testosterone in the care of the critically ill patient.
作者信息
Stevenson R, Bishop D G, Rodseth R N
机构信息
Department of Anaesthesia, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Department of Anaesthesia and Critical Care, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
出版信息
South Afr J Crit Care. 2024 Apr 23;40(1):e1303. doi: 10.7196/SAJCC.2024.v40i1.1303. eCollection 2024.
BACKGROUND
Testosterone is an anabolic and androgenic steroid hormone therapeutically used to produce male sex characteristics. It has also been shown to have a modulating effect on proinflammatory biomarkers. Critical illness is characterised by a proinflammatory and catabolic state and is accompanied by altered testosterone production, which may persist into the recovery phase. Testosterone may, therefore be a potential therapeutic option in critical illness. This paper reviews normal testosterone physiology, and the changes seen during critical illness and systematically reviews testosterone therapy during both the acute and chronic phases of critical illness.
CONTRIBUTION OF THE STUDY
This article explains the pathophysiology of testosterone during critical illness and explores the therapeutic value of testosterone in the management of critically ill patients.
背景
睾酮是一种具有合成代谢和雄激素作用的类固醇激素，在治疗上用于产生男性性征。它还被证明对促炎生物标志物具有调节作用。危重病的特征是促炎和分解代谢状态，并伴有睾酮分泌改变，这种改变可能持续到恢复阶段。因此，睾酮可能是危重病的一种潜在治疗选择。本文回顾了正常睾酮生理学以及危重病期间出现的变化，并系统回顾了危重病急性和慢性期的睾酮治疗。
研究贡献
本文解释了危重病期间睾酮的病理生理学，并探讨了睾酮在危重病患者管理中的治疗价值。
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