Sidhu Jaspreet K, Singh Surjit
Department of Pharmacology, Amrita School of Medicine, Faridabad, Haryana, 121002, India.
Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, 342001, India.
Endocr Metab Immune Disord Drug Targets. 2025;25(4):267-270. doi: 10.2174/0118715303319530240703111013.
Obesity is now recognised as an emerging public health problem across the globe. Its incidence has been growing in the last two decades. Furthermore, as per the obesity treatment guidelines, a comprehensive approach that incorporates behavioural treatment, medications, lifestyle modifications, and/or bariatric surgery is the best way to manage weight. A novel dual agonist of Glucose-dependent insulinotropic peptide (GIP) and Glucagon-like peptide -1 (GLP- 1) receptors, Tirzepatide, was recently approved for the management of obesity. Tirzepatide manages blood sugar levels and enhances weight loss more than GLP-1 receptor agonists.
肥胖现已被公认为全球一个新出现的公共卫生问题。在过去二十年中,其发病率一直在上升。此外,根据肥胖治疗指南,采用行为治疗、药物治疗、生活方式改变和/或减肥手术的综合方法是控制体重的最佳途径。一种新型的葡萄糖依赖性促胰岛素多肽(GIP)和胰高血糖素样肽-1(GLP-1)受体双重激动剂替尔泊肽最近被批准用于治疗肥胖症。与GLP-1受体激动剂相比,替尔泊肽能更好地控制血糖水平并促进体重减轻。