Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York 13210, USA.
J Pediatric Infect Dis Soc. 2024 Jul 12;13(Supplement_2):S110-S114. doi: 10.1093/jpids/piae058.
Newborns and young infants are at risk for severe respiratory syncytial virus (RSV) lower respiratory tract infection. Passive immunity is the mainstay of infection prevention in this cohort. Transplacental transfer of maternal antibodies provides the newborn with immediate protection from life-threatening infections, however, is dependent upon gestational age, birth weight, mother's age, recent maternal vaccination, maternal nutritional status, maternal immunocompetence and medical conditions, and placental integrity. Efficient transplacental transfer of RSV-neutralizing antibodies have led to the development and approval of maternal RSV immunization for the protection of the newborn. Additionally, administration of RSV-specific antibodies to infants leads to high serum titers of RSV-neutralizing antibodies and further protection from severe disease.
新生儿和婴幼儿有发生严重呼吸道合胞病毒（RSV）下呼吸道感染的风险。被动免疫是这一年龄组预防感染的主要手段。母体抗体通过胎盘转移为新生儿提供了对危及生命的感染的即时保护，但这取决于胎龄、出生体重、母亲年龄、近期母亲疫苗接种、母亲营养状况、母亲免疫能力和健康状况以及胎盘完整性。高效的 RSV 中和抗体胎盘转移导致了 RSV 母源免疫的开发和批准，以保护新生儿。此外，向婴儿给予 RSV 特异性抗体可导致 RSV 中和抗体的血清滴度升高，并进一步预防严重疾病。
