快速分子诊断检测对菌血症病原体的早期检测及其对重症监护患者管理效果的评估。
Early detection of bacteremia pathogens with rapid molecular diagnostic tests and evaluation of effect on intensive care patient management.
机构信息
Department of Clinical Microbiology and Infectious Diseases, Health Sciences University Izmir Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Gaziler Street. No: 331, Izmir, Yenişehir, Turkey.
Department of Intensive Care Unit, Health Sciences University Izmir Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkey.
出版信息
Diagn Microbiol Infect Dis. 2024 Sep;110(1):116424. doi: 10.1016/j.diagmicrobio.2024.116424. Epub 2024 Jul 7.
UNLABELLED
İNTRODUCTION: The BioFire FilmArray Blood Culture Identification panel (BCID2), a rapid molecular blood culture identification test based on multiplex nested polymerase chain reaction. The aim of this study was to evaluate clinical outcomes between the period before (pre-BCID2 group) and after (post-BCID2 group) the introduction of the BCID2 panel into our routine practice.
METHODS
The primary endpoint was time to optimal antibiotherapy, and the secondary endpoints were duration of hospital and intensive care unit stay, 7-day, 14-day and 28-day mortality rates after bacteremia.
RESULTS
The median time from empirical antibiotherapy to optimal antimicrobial therapy was 4560 (IQR;3060-7140) minutes in the pre-BCID2 group and 1715 (IQR;1362- 2776.25) minutes (in the post-BCID2 group (p<0.05).
CONCLUSION
Adding the BCID2 panel may improve antibiotic management in critically ill bacteremia patients.
目的
介绍 BioFire FilmArray 血培养鉴定试剂盒（BCID2），这是一种基于多重巢式聚合酶链反应的快速分子血培养鉴定检测方法。本研究旨在评估 BCID2 试剂盒引入常规检测前后（引入前组和引入后组）的临床结局。
方法
主要终点为最佳抗菌治疗的时间，次要终点为菌血症后住院和重症监护病房（ICU）的时间、7 天、14 天和 28 天的死亡率。
结果
引入前组经验性抗菌治疗至最佳抗菌治疗的中位时间为 4560（IQR；3060-7140）分钟，引入后组为 1715（IQR；1362-2776.25）分钟（p<0.05）。
结论
添加 BCID2 试剂盒可能改善危重症菌血症患者的抗生素管理。
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