来自肿柄菊的具有诱导铁死亡活性的倍半萜内酯
Sesquiterpene lactones from Tithonia diversifolia with ferroptosis-inducing activities.
作者信息
Ding Ao-Xue, Shan Yi-Ming, Li Chen-Yue, Qin Guo-Qing, Chen Tong, Wang Qing, Hu Xiang-Gang, Guo Peng-Ju, Yu Hai-Jun, Wang Wen-Qiong, Xuan Li-Jiang
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; School of Pharmacy, Fudan University, Shanghai, 201203, China.
出版信息
Phytochemistry. 2024 Oct;226:114219. doi: 10.1016/j.phytochem.2024.114219. Epub 2024 Jul 10.
Eight previously undescribed sesquiterpene lactones (1-8), together with six known ones (9-14) were isolated from the aerial parts of Tithonia diversifolia (Hemsl.) A. Gray. The absolute configurations of these compounds were elucidated using HRMS, NMR spectroscopy, optical rotation measurements, X-ray crystallography, and ECD. Among them, sesquiterpene lactones 2-4 share a unique carbon skeleton with a rare C-3/C-4 ring-opened structure. Compounds 1 and 8 showed moderate inhibitory effects toward CT26 murine colon carcinoma cells by promoting lipid ROS production, highlighting their potential as ferroptosis inducers.
从异叶肿柄菊（Tithonia diversifolia (Hemsl.) A. Gray）的地上部分分离出8个前所未有的倍半萜内酯（1-8）以及6个已知的倍半萜内酯（9-14）。利用高分辨质谱、核磁共振光谱、旋光测定、X射线晶体学和电子圆二色谱对这些化合物的绝对构型进行了阐释。其中，倍半萜内酯2-4具有独特的碳骨架，带有罕见的C-3/C-4开环结构。化合物1和8通过促进脂质活性氧的产生对CT26小鼠结肠癌细胞显示出中等抑制作用，突出了它们作为铁死亡诱导剂的潜力。
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