Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning 110004, PR China.
Department of Neurosurgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning 110004, PR China.
Biomed Pharmacother. 2024 Aug;177:117144. doi: 10.1016/j.biopha.2024.117144. Epub 2024 Jul 14.
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder and the leading cause of age-related cognitive decline. Recent studies have established a close relationship between mitophagy and the pathogenesis of AD. Various phytochemicals have shown promising therapeutic effects in mitigating the onset and progression of AD. This review offers a comprehensive overview of the typical features of mitophagy and the underlying mechanisms leading to its occurrence in AD, highlighting its significance in the disease's pathogenesis and progression. Additionally, we examine the therapeutic mechanisms of synthetic drugs that induce mitophagy in AD. Finally, we summarize recent advances in research on phytochemicals that regulate mitophagy in the treatment of AD, potentially guiding the development of new anti-AD drugs.
阿尔茨海默病（AD）是一种常见的神经退行性疾病，也是与年龄相关的认知能力下降的主要原因。最近的研究已经确定了自噬与 AD 发病机制之间的密切关系。各种植物化学物质已显示出在减轻 AD 的发病和进展方面具有有希望的治疗效果。本综述全面概述了自噬的典型特征和导致 AD 发生的潜在机制，强调了其在疾病发病机制和进展中的重要性。此外，我们研究了诱导 AD 中自噬的合成药物的治疗机制。最后，我们总结了最近在调节 AD 中自噬的植物化学物质研究方面的进展，这可能为开发新的抗 AD 药物提供指导。
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