Department of Ophthalmology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of Ophthalmology, King Saud University, Riyadh, Saudi Arabia.
Middle East Afr J Ophthalmol. 2024 Jun 14;30(2):121-124. doi: 10.4103/meajo.meajo_69_23. eCollection 2023 Apr-Jun.
Chronic myeloid leukemia (CML) is a malignant proliferative disorder involving the bone marrow and lymphatic system. Retinal involvement is a rare form of presentation in patients with CML. We report a case of a 49-year-old woman who presented with an acute bilateral visual disturbance. Her initial visual acuity was 20/20 in both eyes. Fundus examination revealed multiple yellowish retinal infiltrates, vascular sheathing, and peripheral sclerosed blood vessels. Fundus fluorescein angiography revealed bilateral peripheral retinal ischemia. Optical coherence tomography of the macula showed varying sizes of hyperreflective lesions distributed within the inner and outer retinal layers and in the subretinal space. Systemic workup revealed marked leukocytosis, and bone marrow biopsy revealed CML. Patients with CML can rarely present with ocular symptoms. Early recognition and prompt referral are crucial in lifesaving.
慢性髓细胞白血病（CML）是一种涉及骨髓和淋巴系统的恶性增殖性疾病。视网膜受累是 CML 患者的一种罕见表现形式。我们报告了一例 49 岁女性，她因急性双侧视力障碍就诊。她的初始视力在双眼均为 20/20。眼底检查显示多发性黄色视网膜浸润、血管鞘和周围硬化的血管。眼底荧光血管造影显示双侧周边视网膜缺血。黄斑区光学相干断层扫描显示在内、外视网膜层和视网膜下空间分布着不同大小的高反射病变。系统检查显示白细胞明显增多，骨髓活检显示 CML。CML 患者偶尔会出现眼部症状。早期识别和及时转诊对于挽救生命至关重要。
