Esnault Vincent
Service de néphrologie-dialysetransplantation, CHU, Nice, France.
Rev Prat. 2024 Jun;74(6):s19-s22.
RENIN-ANGIOTENSINALDOSTERONE SYSTEM BLOCKADE AND BEYOND. Patients with chronic kidney disease (CKD) require both etiological and symptomatic treatments to slow renal function decline. Reductions of protein and salt intakes are required. Pharmacological treatments combines blockade of the renin-angiotensin system, sodium-glucose co-transporter type 2 inhibitors and mineralocorticoid receptor antagonists in most diabetic patients. The albumin creatinine ration (ACR) in morning spot urine samples is now a therapeutic target both in diabetic and non-diabetic CKD patients.
肾素-血管紧张素-醛固酮系统阻断及其他。慢性肾脏病(CKD)患者需要病因治疗和对症治疗以减缓肾功能下降。需要减少蛋白质和盐的摄入量。在大多数糖尿病患者中,药物治疗联合应用肾素-血管紧张素系统阻断剂、钠-葡萄糖协同转运蛋白2抑制剂和盐皮质激素受体拮抗剂。晨尿样本中的白蛋白肌酐比值(ACR)目前是糖尿病和非糖尿病CKD患者的治疗靶点。