非对比螺旋式乳腺 CT 探测病变密度以提高乳腺癌检出率的潜力：一项初步研究。
Potential of non-contrast spiral breast CT to exploit lesion density and favor breast cancer detection: A pilot study.
机构信息
Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; GZO AG Spital Wetzikon, Spitalstrasse 66, Wetzikon 8620, Switzerland.
出版信息
Eur J Radiol. 2024 Sep;178:111614. doi: 10.1016/j.ejrad.2024.111614. Epub 2024 Jul 14.
PURPOSE
To assess the density values of breast lesions and breast tissue using non-contrast spiral breast CT (nc-SBCT) imaging.
METHOD
In this prospective study women undergoing nc-SBCT between April-October 2023 for any purpose were included in case of: histologically proven malignant lesion (ML); fibroadenoma (FA) with histologic confirmation or stability > 24 months (retrospectively); cysts with ultrasound correlation; and women with extremely dense breast (EDB) and no sonographic findings. Three regions of interest were placed on each lesion and 3 different area of EDB. The evaluation was performed by two readers (R1 and R2). Kruskal-Wallis test, intraclass correlation (ICC) and ROC analysis were used.
RESULTS
40 women with 12 ML, 10 FA, 15 cysts and 9 with EDB were included. Median density values and interquartile ranges for R1 and R2 were: 60.2 (53.3-67.3) and 62.5 (55.67-76.3) HU for ML; 46.3 (41.9-59.5) and 44.5 (40.5-59.8) HU for FA; 35.3 (24.3-46.0) and 39.7 (26.7-52.0) HU for cysts; and 28.7 (24.2-33.0) and 33.3 (31.7-36.8) HU for EDB. For both readers, densities were significantly different for ML versus EDB (p < 0.001) and cysts (p < 0.001) and for FA versus EDB (p=/<0.003). The AUC was 0.925 (95 %CI 0.858-0.993) for R1 and 0.942 (0.884-1.00) for R2 when comparing ML versus others and 0.792 (0.596-0.987) and 0.833 (0.659-1) when comparing ML versus FA. The ICC showed an almost perfect inter-reader (0.978) and intra-reader agreement (>0.879 for both readers).
CONCLUSIONS
In nc-SBCT malignant lesions have higher density values compared to normal tissue and measurements of density values are reproducible between different readers.
目的
使用非对比螺旋式乳腺 CT（nc-SBCT）成像评估乳腺病变和乳腺组织的密度值。
方法
在这项前瞻性研究中，纳入了 2023 年 4 月至 10 月间因任何原因接受 nc-SBCT 检查的女性，如果符合以下情况，则纳入病例组：经组织学证实的恶性病变（ML）；经组织学证实或稳定性＞24 个月的纤维腺瘤（FA）（回顾性）；与超声相关的囊肿；以及乳腺极度致密（EDB）且无超声发现的女性。在每个病变和 EDB 的 3 个不同区域放置 3 个感兴趣区域。由 2 位读者（R1 和 R2）进行评估。使用 Kruskal-Wallis 检验、组内相关系数（ICC）和 ROC 分析进行分析。
结果
共纳入 40 名女性，其中 12 名为 ML，10 名为 FA，15 名为囊肿，9 名为 EDB。R1 和 R2 的中位数密度值和四分位距分别为：ML 为 60.2（53.3-67.3）和 62.5（55.67-76.3）HU；FA 为 46.3（41.9-59.5）和 44.5（40.5-59.8）HU；囊肿为 35.3（24.3-46.0）和 39.7（26.7-52.0）HU；EDB 为 28.7（24.2-33.0）和 33.3（31.7-36.8）HU。对于两位读者，ML 与 EDB（p＜0.001）和囊肿（p＜0.001）之间的密度值差异有统计学意义，FA 与 EDB（p＜0.003）之间的密度值差异有统计学意义。R1 比较 ML 与其他病变的 AUC 为 0.925（95%CI 0.858-0.993），R2 为 0.942（0.884-1.00），而 R1 比较 ML 与 FA 的 AUC 为 0.792（0.596-0.987），R2 为 0.833（0.659-1）。ICC 显示读者间的一致性近乎完美（0.978），读者内的一致性＞0.879（两位读者均如此）。
结论
在 nc-SBCT 中，恶性病变的密度值高于正常组织，且不同读者之间的密度值测量具有可重复性。
Zotero 插件