Gu Yang, Mu Qing, Cheng Dali
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, P.R. China.
iScience. 2024 Jun 1;27(7):110155. doi: 10.1016/j.isci.2024.110155. eCollection 2024 Jul 19.
This comprehensive review delves into the significance of androgens in cervical cancer, examining both epidemiological evidence and the underlying biological mechanisms. Cervical cancer ranks as the fourth most prevalent cancer among women globally, with disproportionately higher incidence and mortality rates in less developed regions where cervical human papillomavirus (HPV) screening remains limited. Recent research highlights the previously underexplored role of androgens in cervical cancer. Notably, cervical tissues house androgen receptors, and elevated levels of endogenous androgens have been linked to an increased risk of cervical cancer. Androgens exert their influence on the development and progression of cervical cancer by impacting key cellular processes, including proliferation, apoptosis, differentiation, and epithelial cell transformation. Furthermore, specific HPV subtypes may interact with androgens, potentially modulating HPV-related cellular degeneration and transformation. In light of these findings, it is evident that androgens assume a crucial role in cervical cancer's pathogenesis. Consequently, further investigations are warranted to deepen our understanding of the intricate relationship between androgens and cervical cancer. Such knowledge advancements can facilitate improved strategies for early prevention and treatment of cervical cancer, especially in regions with limited HPV screening access. This review underscores the importance of considering androgens as a vital component of the multifaceted landscape of cervical cancer etiology and progression, ultimately contributing to more effective clinical interventions.
这篇综述深入探讨了雄激素在宫颈癌中的重要性，研究了流行病学证据和潜在的生物学机制。宫颈癌是全球女性中第四大常见癌症，在宫颈癌人类乳头瘤病毒（HPV）筛查仍然有限的欠发达地区，其发病率和死亡率高得不成比例。最近的研究突出了雄激素在宫颈癌中此前未被充分探索的作用。值得注意的是，宫颈组织中存在雄激素受体，内源性雄激素水平升高与宫颈癌风险增加有关。雄激素通过影响关键细胞过程，包括增殖、凋亡、分化和上皮细胞转化，对宫颈癌的发生和发展产生影响。此外，特定的HPV亚型可能与雄激素相互作用，潜在地调节HPV相关的细胞变性和转化。鉴于这些发现，显然雄激素在宫颈癌的发病机制中起着关键作用。因此，有必要进行进一步研究，以加深我们对雄激素与宫颈癌之间复杂关系的理解。这种知识的进步可以促进改进宫颈癌的早期预防和治疗策略，特别是在HPV筛查机会有限的地区。这篇综述强调了将雄激素视为宫颈癌病因和进展多方面情况的重要组成部分的重要性，最终有助于更有效的临床干预。
