Retraction: Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease.
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PLoS Negl Trop Dis. 2024 Jul 23;18(7):e0012360. doi: 10.1371/journal.pntd.0012360. eCollection 2024 Jul.
Abstract
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Retraction: Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease.撤回声明：口服GW788388（一种转化生长因子β信号通路抑制剂）可预防恰加斯病中的心脏纤维化。
PLoS Negl Trop Dis. 2024 Jul 23;18(7):e0012360. doi: 10.1371/journal.pntd.0012360. eCollection 2024 Jul.
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Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.口服转化生长因子-β信号抑制剂 GW788388 可预防恰加斯病性心脏病纤维化。
PLoS Negl Trop Dis. 2012;6(6):e1696. doi: 10.1371/journal.pntd.0001696. Epub 2012 Jun 12.
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TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease.在一项慢性恰加斯心脏病的临床前研究中，TGF-β 抑制剂治疗可减少纤维化并刺激心脏改善。
PLoS Negl Trop Dis. 2019 Jul 31;13(7):e0007602. doi: 10.1371/journal.pntd.0007602. eCollection 2019 Jul.
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Effects of TGF-β1 Receptor Inhibitor GW788388 on the Epithelial to Mesenchymal Transition of Peritoneal Mesothelial Cells.TGF-β1 受体抑制剂 GW788388 对腹膜间皮细胞上皮-间充质转化的影响。
Int J Mol Sci. 2021 Apr 29;22(9):4739. doi: 10.3390/ijms22094739.
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Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.口服GW788388（一种转化生长因子-β I型和II型受体激酶抑制剂）可减轻肾纤维化。
Kidney Int. 2008 Mar;73(6):705-15. doi: 10.1038/sj.ki.5002717. Epub 2007 Dec 12.
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Transforming growth factor β receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease.转化生长因子β受体抑制可预防进行性心脏传导疾病小鼠模型中的心室纤维化。
Cardiovasc Res. 2017 Apr 1;113(5):464-474. doi: 10.1093/cvr/cvx026.
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In Chagas disease, transforming growth factor beta neutralization reduces infection and improves cardiac performance.在恰加斯病中，转化生长因子β中和可减少感染并改善心脏功能。
Front Cell Infect Microbiol. 2022 Nov 30;12:1017040. doi: 10.3389/fcimb.2022.1017040. eCollection 2022.
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Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease.转化生长因子-β信号通路的药理学抑制可减少急性恰加斯病的感染并预防心脏损伤。
Antimicrob Agents Chemother. 2009 Nov;53(11):4694-701. doi: 10.1128/AAC.00580-09. Epub 2009 Sep 8.
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The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice.TGFβ1 受体拮抗剂 GW788388 可减少 JNK 激活并保护小鼠免受对乙酰氨基酚肝毒性的损害。
Toxicol Sci. 2019 May 1;170(2):549-561. doi: 10.1093/toxsci/kfz122.
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Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor.4-{4-[3-(吡啶-2-基)-1H-吡唑-4-基]吡啶-2-基}-N-(四氢-2H-吡喃-4-基)苯甲酰胺（GW788388）的发现：一种强效、选择性且口服活性的转化生长因子-β I型受体抑制剂。
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Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.口服转化生长因子-β信号抑制剂 GW788388 可预防恰加斯病性心脏病纤维化。
PLoS Negl Trop Dis. 2012;6(6):e1696. doi: 10.1371/journal.pntd.0001696. Epub 2012 Jun 12.
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