Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
Heart Valve Department, ETB-BISLIFE, Beverwijk, The Netherlands.
Cephalalgia. 2024 Jul;44(7):3331024241254088. doi: 10.1177/03331024241254088.
Migraine prevalence and levels of calcitonin gene-related peptide (CGRP), a peptide involved in migraine pathophysiology, differ between men and women, and appear to be affected by changes in sex hormones. The present study investigated the sex-specific responses to CGRP in human isolated arteries.
CGRP-induced relaxation of 62 (28 men and 34 women) human isolated middle meningeal arteries (HMMA) and 139 (69 men and 70 women) human isolated coronary arteries (HCA) was compared between men and women in groups <50 years and ≥50 years of age as a proxy for pre- and postmenopausal status in women, as well as matched-age groups for men.
In HCA, no differences were observed between male and female tissue, or between the different age groups. However, in HMMA, the maximum response was significantly smaller and CGRP was less potent in females <50 compared with males <50 years of age. No differences were observed between the older age groups.
Sex differences were observed for CGRP-induced relaxation of HMMA, but not HCA. These differences could arise from differential receptor expression in the vascular beds combined with the effect of sex hormones on CGRP and subsequent receptor desensitization.
偏头痛的患病率和降钙素基因相关肽（CGRP）的水平存在性别差异，CGRP 是一种参与偏头痛病理生理学的肽，似乎受性激素变化的影响。本研究旨在研究 CGRP 在人离体动脉中的性别特异性反应。
比较了<50 岁和≥50 岁女性（作为绝经前后的代表）以及男性同龄组之间，62 条（28 名男性和 34 名女性）人离体脑膜中动脉（HMMA）和 139 条（69 名男性和 70 名女性）人离体冠状动脉（HCA）中 CGRP 诱导的松弛反应。
在 HCA 中，男性和女性组织之间，或不同年龄组之间均未观察到差异。然而，在 HMMA 中，<50 岁的女性与<50 岁的男性相比，最大反应明显较小，CGRP 的效力也较低。年龄较大的组之间未观察到差异。
HMMA 中 CGRP 诱导的松弛反应存在性别差异，但 HCA 中不存在。这些差异可能源于血管床中受体表达的差异，以及性激素对 CGRP 的影响及其随后的受体脱敏。
