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三虫原虫胎儿分离株的比较膜蛋白质组分析。

Comparative membrane proteomic analysis of Tritrichomonas foetus isolates.

机构信息

Laboratorio de Biología Molecular, Inmunología y Microbiología (LaBIM), Instituto Multidisciplinario de Salud, Tecnología y Desarrollo (IMSaTeD), CONICET-UNSE, Santiago del Estero, Argentina.

Facultad de Ciencias Médicas (FCM-UNSE), Santiago del Estero, Argentina.

出版信息

Sci Rep. 2024 Jul 24;14(1):17033. doi: 10.1038/s41598-024-67827-8.

DOI:10.1038/s41598-024-67827-8
PMID:39043862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11266394/
Abstract

Tritrichomonas foetus is a flagellated and anaerobic parasite able to infect cattle and felines. Despite its prevalence, there is no effective standardized or legal treatment for T. foetus-infected cattle; the vaccination still has limited success in mitigating infections and reducing abortion risk; and nowadays, the diagnosis of T. foetus presents important limitations in terms of sensitivity and specificity in bovines. Here, we characterize the plasma membrane proteome of T. foetus and identify proteins that are represented in different isolates of this protozoan. Additionally, we performed a bioinformatic analysis that revealed the antigenicity potential of some of those proteins. This analysis is the first study to identify common proteins at the plasma membrane of different T. foetus isolates that could be targets for alternative diagnostic or vaccine techniques in the future.

摘要

胎儿三毛滴虫是一种有鞭毛的厌氧寄生虫，能够感染牛和猫科动物。尽管它很普遍，但目前尚无针对感染胎儿三毛滴虫的牛的有效标准化或合法治疗方法；疫苗接种在减轻感染和降低流产风险方面仍然收效有限；如今，胎儿三毛滴虫的诊断在牛中的灵敏度和特异性方面存在重要限制。在这里，我们描述了胎儿三毛滴虫的质膜蛋白质组，并鉴定了在该原生动物的不同分离株中存在的蛋白质。此外，我们进行了生物信息学分析，揭示了其中一些蛋白质的抗原性潜力。这项分析是首次鉴定不同胎儿三毛滴虫分离株质膜上的共同蛋白，这些蛋白可能成为未来替代诊断或疫苗技术的靶标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/4398ab4a15fc/41598_2024_67827_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/9d448bbcf643/41598_2024_67827_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/980b6cee98a0/41598_2024_67827_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/fd4356a4acd8/41598_2024_67827_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/e3b3fc83485c/41598_2024_67827_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/4398ab4a15fc/41598_2024_67827_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/9d448bbcf643/41598_2024_67827_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/980b6cee98a0/41598_2024_67827_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/fd4356a4acd8/41598_2024_67827_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/e3b3fc83485c/41598_2024_67827_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ae/11266394/4398ab4a15fc/41598_2024_67827_Fig5_HTML.jpg

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