重症 COVID-19 患者中单纯疱疹病毒和巨细胞病毒肺部再激活：治疗还是不治疗？这（仍然）是个问题。 - Suppr

Herpes simplex virus and cytomegalovirus lung reactivations in severe COVID-19 patients: to treat or not to treat? That is (still) the question.

作者信息

Luyt Charles-Edouard, Girardis Massimo, Paixão Paulo

机构信息

Médecine Intensive Réanimation, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique - Hôpitaux de Paris (AP-HP), Sorbonne Université, Paris, France.

INSERM UMRS_1166-iCAN, Institute of Cardiometabolism and Nutrition, Paris, France.

出版信息

Intensive Care Med. 2024 Aug;50(8):1317-1319. doi: 10.1007/s00134-024-07562-w. Epub 2024 Jul 24.

DOI:10.1007/s00134-024-07562-w

PMID:39046488

Abstract

摘要

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Herpes simplex virus and cytomegalovirus lung reactivations in severe COVID-19 patients: to treat or not to treat? That is (still) the question.重症 COVID-19 患者中单纯疱疹病毒和巨细胞病毒肺部再激活：治疗还是不治疗？这（仍然）是个问题。

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Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19.COVID-19 相关急性呼吸窘迫综合征患者中的肺单纯疱疹病毒和巨细胞病毒。

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BMJ Case Rep. 2013 May 9;2013:bcr2012007942. doi: 10.1136/bcr-2012-007942.

Congenital Cytomegalovirus and Neonatal Herpes Simplex Virus Infections: To Treat or Not to Treat?先天性巨细胞病毒和新生儿单纯疱疹病毒感染：治疗还是不治疗？

Pediatr Infect Dis J. 2019 Jun;38(6S Suppl 1):S60-S63. doi: 10.1097/INF.0000000000002325.

Vulval cytomegalovirus coexisting with herpes simplex virus in a patient with human immunodeficiency virus infection.一名人类免疫缺陷病毒感染患者的外阴巨细胞病毒与单纯疱疹病毒共存。

BJOG. 2003 Dec;110(12):1123-4.

Herpes simplex virus infection during foscarnet therapy.膦甲酸治疗期间的单纯疱疹病毒感染。

J Infect Dis. 1992 Aug;166(2):447-8. doi: 10.1093/infdis/166.2.447.

Are varicella zoster and herpes simplex sentinel lesions for cytomegalovirus in renal transplant recipients?水痘带状疱疹和单纯疱疹是肾移植受者巨细胞病毒的哨兵病变吗？

Lancet. 1995 Sep 30;346(8979):914-5. doi: 10.1016/s0140-6736(95)92766-2.

In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections.1-O-十六烷基丙二醇-3-磷酸更昔洛韦和1-O-十六烷基丙二醇-3-磷酸喷昔洛韦在巨细胞病毒和单纯疱疹病毒感染中的体外和体内活性

Antivir Chem Chemother. 2001 Jan;12(1):61-70. doi: 10.1177/095632020101200104.

Human herpes viruses in burn patients: A systematic review.烧伤患者中的人类疱疹病毒：一项系统综述。

Burns. 2017 Feb;43(1):25-33. doi: 10.1016/j.burns.2016.02.003. Epub 2016 Aug 8.

Fulminant hepatic failure secondary to herpes simplex virus infection in a neonate: A case report of successful treatment with liver transplantation and perioperative acyclovir.新生儿单纯疱疹病毒感染继发暴发性肝衰竭：肝移植及围手术期使用阿昔洛韦成功治疗的病例报告

Liver Transpl Surg. 1998 Nov;4(6):513-5. doi: 10.1002/lt.500040601.

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Intensive Care Med. 2024 Aug;50(8):1251-1264. doi: 10.1007/s00134-024-07529-x. Epub 2024 Jul 17.

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Intensive Care Med Exp. 2024 Apr 22;12(1):40. doi: 10.1186/s40635-024-00624-9.

Herpesviridae lung reactivation and infection in patients with severe COVID-19 or influenza virus pneumonia: a comparative study.严重新型冠状病毒肺炎或流感病毒肺炎患者中疱疹病毒科肺部再激活与感染：一项比较研究

Ann Intensive Care. 2022 Sep 24;12(1):87. doi: 10.1186/s13613-022-01062-0.

Characteristics and prognosis of bloodstream infection in patients with COVID-19 admitted in the ICU: an ancillary study of the COVID-ICU study.入住重症监护病房的新型冠状病毒肺炎患者血流感染的特征与预后：新型冠状病毒肺炎重症监护病房研究的一项辅助研究

Ann Intensive Care. 2021 Dec 24;11(1):183. doi: 10.1186/s13613-021-00971-w.

HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients.单纯疱疹病毒 1 型（HSV-1）再激活与危重症 COVID-19 患者的死亡率和肺炎风险增加相关。

Crit Care. 2021 Dec 6;25(1):417. doi: 10.1186/s13054-021-03843-8.

Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study.COVID-19 机械通气患者真菌感染：法国多中心 MYCOVID 研究。

Lancet Respir Med. 2022 Feb;10(2):180-190. doi: 10.1016/S2213-2600(21)00442-2. Epub 2021 Nov 26.

Herpes Simplex Virus Re-Activation in Patients with SARS-CoV-2 Pneumonia: A Prospective, Observational Study.新型冠状病毒肺炎患者的单纯疱疹病毒再激活：一项前瞻性观察研究。

Microorganisms. 2021 Sep 7;9(9):1896. doi: 10.3390/microorganisms9091896.

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Intensive Care Med. 2021 Feb;47(2):188-198. doi: 10.1007/s00134-020-06323-9. Epub 2021 Jan 3.

Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis.抗病毒治疗对呼吸道检测到单纯疱疹病毒的机械通气患者结局的影响：系统评价和荟萃分析。

Crit Care. 2020 Sep 29;24(1):584. doi: 10.1186/s13054-020-03296-5.

Acyclovir for Mechanically Ventilated Patients With Herpes Simplex Virus Oropharyngeal Reactivation: A Randomized Clinical Trial.阿昔洛韦治疗机械通气患者单纯疱疹病毒口腔复发：一项随机临床试验。

JAMA Intern Med. 2020 Feb 1;180(2):263-272. doi: 10.1001/jamainternmed.2019.5713.

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Herpes simplex virus and cytomegalovirus lung reactivations in severe COVID-19 patients: to treat or not to treat? That is (still) the question.

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