CYP17A1 基因 rs743572 上 GG 基因型调控 T/E 比值降低可作为 MetS-BPH 的独立危险因素：一项回顾性队列研究。

The GG genotype of rs743572 in CYP17A1 gene regulating the decrease of T/E ratio can be an independent risk factor for MetS-BPH: a retrospective cohort study.

机构信息

Department of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, China.

Department of Urology, People's Hospital of Wuchuan County, Wuchuan, Guizhou, 564300, China.

出版信息

World J Urol. 2024 Jul 24;42(1):439. doi: 10.1007/s00345-024-05138-3.

DOI:10.1007/s00345-024-05138-3

PMID:39046536

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11269469/

Abstract

PURPOSE

To confirm if the CYP17A1 gene regulates the ratio of T/E leading to MetS-BPH.

METHODS

824 men, aged 47-88 years, were recruited into this study through consecutive routine physical examination programs and long-term outpatient screening. Several parameters, including SNPs of CYP17A1 gene, total testosterone, estradiol, and the ratio of total testosterone to estradiol (T/E) were obtained for each participant. Based on the diagnosis of BPH, MetS, and MetS-BPH, the participants were divided into BPH and non-BPH groups, MetS and non-MetS groups, and MetS-BPH and non-MetS-BPH groups. Values of the obtained parameters were evaluated using one-way analysis of variance, Student's t-test, Chi-squared test, and logistic regression analysis.

RESULTS

SNPs of the CYP17A1 gene, including the rs743572 genotypes (GG, GA, and AA), rs3781287 genotypes (GG, GT, TT), and rs4919686 genotypes (CC, CA, and AA), were present in every group. Only the GG genotype of rs743572 was independently associated with BPH (OR = 5.868, 95% CI: 3.363-7.974, P < 0.001), MetS (OR = 7.228, 95% CI: 3.925-11.331, P < 0.001), and MetS-BPH (OR = 3.417, 95% CI: 1.783-5.266, P < 0.001) after adjusting for age. In the population of genotype GG of rs743572, the decrease in T/E ratio was an independent risk factor for BPH (OR = 839.756, 95% CI: 36.978-1334.263, P = 0.001), MetS (OR = 376.988, 95% CI: 12.980-488.976, P < 0.003), and MetS-BPH (OR = 388.236, 95% CI: 24.869-495.363, P = 0.003).

CONCLUSION

The GG genotype of rs743572 in CYP17A1 gene regulating the decrease of T/E ratio can be an independent risk factor for MetS-BPH populations.

TRIAL REGISTRATION NUMBER

ChiCTR2200057632 "retrospectively registered".

DATE OF REGISTRATION

March 15, 2022 "retrospectively registered".

摘要

目的

确认 CYP17A1 基因是否调节导致 MetS-BPH 的 T/E 比值。

方法

本研究通过连续的常规体检计划和长期门诊筛查，招募了 824 名年龄在 47-88 岁的男性。为每位参与者获得了 CYP17A1 基因的 SNPs、总睾酮、雌二醇和总睾酮与雌二醇（T/E）的比值等参数。根据 BPH、MetS 和 MetS-BPH 的诊断，将参与者分为 BPH 和非 BPH 组、MetS 和非 MetS 组以及 MetS-BPH 和非 MetS-BPH 组。使用单因素方差分析、学生 t 检验、卡方检验和 logistic 回归分析评估获得的参数值。

结果

CYP17A1 基因的 SNPs，包括 rs743572 基因型（GG、GA 和 AA）、rs3781287 基因型（GG、GT 和 TT）和 rs4919686 基因型（CC、CA 和 AA），存在于每个组中。只有 rs743572 的 GG 基因型与 BPH（OR=5.868，95%CI：3.363-7.974，P<0.001）、MetS（OR=7.228，95%CI：3.925-11.331，P<0.001）和 MetS-BPH（OR=3.417，95%CI：1.783-5.266，P<0.001）独立相关，在调整年龄后。在 rs743572 的 GG 基因型人群中，T/E 比值降低是 BPH（OR=839.756，95%CI：36.978-1334.263，P=0.001）、MetS（OR=376.988，95%CI：12.980-488.976，P<0.003）和 MetS-BPH（OR=388.236，95%CI：24.869-495.363，P=0.003）的独立危险因素。