Department of Audiology, Sri Ramachandra Faculty of Audiology and Speech Language Pathology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, India.
Department of Radiation Oncology, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, India.
Am J Audiol. 2024 Sep 3;33(3):1041-1069. doi: 10.1044/2024_AJA-24-00028. Epub 2024 Jul 25.
The aim of the current scoping review is to identify the studies reporting ototoxicity monitoring in individuals with head and neck cancer (HNC) undergoing radiation therapy and/or chemoradiation therapy across the world. The specific objectives were to identify and report the test protocol used, identify the most common timeline of follow-up, and identify barriers and facilitators influencing the implementation of the monitoring program.
A comprehensive search was conducted across six electronic databases, including PubMed, Embase, Web of Science, Scopus, Google Scholar, and ProQuest. The scoping review method adhered to relevant guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) and frameworks. The database search was carried out by two independent researchers, and studies were selected based on specific inclusion and exclusion criteria.
This scoping review identified 13 studies that fulfilled the inclusion criteria of this study. Only one study reported findings from the perspective of ototoxicity monitoring. Another study explicitly mentioned that ototoxicity monitoring was a standard of care in their hospital. Only one study reported using the relevant guidelines for monitoring ototoxicity. Specialized tests such as high-frequency audiometry, distortion product otoacoustic emissions, and vestibular tests were rarely used. Ototoxicity monitoring was influenced by awareness-related factors, technical factors, treatment-related factors, and organizational factors.
Research on ototoxicity monitoring programs is in its early stages, highlighting the need for standardized practices and multidisciplinary collaboration to enhance health care services for HNC patients. A standardized approach, improved awareness, and the incorporation of patient perspectives are crucial to enhancing ototoxicity monitoring in HNC patients.
本范围综述的目的是识别在全球范围内接受放射治疗和/或放化疗的头颈部癌症（HNC）患者中报告耳毒性监测的研究。具体目标是确定和报告所使用的测试方案，确定最常见的随访时间线，并确定影响监测计划实施的障碍和促进因素。
我们在六个电子数据库（包括 PubMed、Embase、Web of Science、Scopus、Google Scholar 和 ProQuest）中进行了全面搜索。范围综述方法遵循相关指南（系统评价和荟萃分析扩展的首选报告项目）和框架。数据库搜索由两名独立研究人员进行，根据具体的纳入和排除标准选择研究。
本范围综述确定了 13 项符合本研究纳入标准的研究。只有一项研究从耳毒性监测的角度报告了研究结果。另一项研究明确提到，耳毒性监测是他们医院的标准护理。只有一项研究报告使用了监测耳毒性的相关指南。很少使用专门的测试，如高频测听、畸变产物耳声发射和前庭测试。耳毒性监测受到与意识相关的因素、技术因素、治疗相关因素和组织因素的影响。
耳毒性监测计划的研究仍处于早期阶段，强调需要标准化实践和多学科合作，以增强 HNC 患者的医疗服务。标准化方法、提高意识以及纳入患者观点对于增强 HNC 患者的耳毒性监测至关重要。
