鼓室内利多卡因治疗突发性聋伴耳鸣的疗效观察：一项双盲、随机临床试验。
Intratympanic Lidocaine as a Potent Remedy for Tinnitus in Sudden Sensorineural Hearing Loss: A Double-Blind, Randomized Clinical Trial.
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Meishan Municipal People's Hospital, Meishan, Sichuan, China.
出版信息
Otol Neurotol. 2024 Sep 1;45(8):849-854. doi: 10.1097/MAO.0000000000004283. Epub 2024 Jul 25.
OBJECTIVE
This study evaluates intratympanic lidocaine's efficacy and safety for tinnitus relief in sudden sensorineural hearing loss (SSNHL) patients.
METHODS
In a double-blind randomized controlled trial, 100 SSNHL patients with unilateral tinnitus received either intratympanic lidocaine or saline plus usual care. Treatment impact was assessed at 1 and 3 months using the Tinnitus Handicap Inventory, subjective visual analog scale, pure-tone audiometry.
RESULTS
The lidocaine group demonstrated significant tinnitus relief according to the Tinnitus Handicap Inventory and visual analog scale, without pure-tone audiometry improvement or serious adverse events throughout the study period.
CONCLUSION
Intratympanic lidocaine provides a safe, efficacious treatment option for SSNHL tinnitus. Further studies should refine the dosage and delivery parameters because of SSNHL's heterogenous nature.
目的
本研究旨在评估鼓室内利多卡因治疗突发性聋伴耳鸣患者的疗效和安全性。
方法
采用双盲随机对照试验，将 100 例单侧突发性聋伴耳鸣患者随机分为鼓室内利多卡因组和生理盐水组，均给予常规治疗。采用耳鸣残疾评估量表、主观视觉模拟评分和纯音测听评估治疗效果，分别于治疗后 1 个月和 3 个月进行评估。
结果
与生理盐水组相比，鼓室内利多卡因组患者的耳鸣程度在治疗后 1 个月和 3 个月时均显著减轻，而纯音测听无明显改善，且整个研究过程中未出现严重不良反应。
结论
鼓室内利多卡因治疗突发性聋伴耳鸣是一种安全、有效的方法。由于突发性聋的异质性，需要进一步研究来优化利多卡因的剂量和给药参数。
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