Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, PR China; Key National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, PR China.
Department of Pharmacology, School of Medicine, Shandong University, Jinan 250012, PR China.
Int J Biol Macromol. 2024 Oct;277(Pt 3):134141. doi: 10.1016/j.ijbiomac.2024.134141. Epub 2024 Jul 23.
Sodium alginate has good biocompatibility and is widely used in the study of drug carriers. In this paper, a method to prepare calcium alginate microspheres with high sphericity based on double emulsion droplets was proposed, in which sodium alginate is used as the innermost phase. By adjusting the density of the system, the double-emulsion droplets could be suspended in the collecting solution, leading to the homogeneous reaction between the sodium alginate droplets and the calcium ions. By changing the flow rate, the size of the droplets could be changed, and by changing the concentration of calcium ions in the collecting solution, the sphericity of the calcium alginate microspheres could be changed. Then the swelling properties and drug release properties of calcium alginate microspheres were determined. The drug delivery study revealed that the insulin-loaded Ca-Alginate microspheres were able to decrease blood glucose by 41.4 % after oral administration to mice. Thus, the Ca-Alginate microsphere is a suitable candidate for controlled pH-sensitive drug delivery.
海藻酸钠具有良好的生物相容性，广泛应用于药物载体的研究。本文提出了一种基于双乳液滴制备高圆整度海藻酸钠微球的方法，其中海藻酸钠作为最内层。通过调节体系的密度，使双乳液滴悬浮在收集溶液中，导致海藻酸钠液滴与钙离子均匀反应。通过改变流速可以改变液滴的大小，通过改变收集溶液中钙离子的浓度可以改变海藻酸钙微球的圆整度。然后测定了海藻酸钙微球的溶胀性能和药物释放性能。药物递送研究表明，载胰岛素的 Ca-Alginate 微球经口服给予小鼠后，可使血糖降低 41.4%。因此，Ca-Alginate 微球是一种适合 pH 敏感控制药物递送的候选材料。
