Phytomedicine Research Laboratory, Department of Pharmaceutical Engineering & Technology, IIT (BHU), Varanasi, 221005, Uttar Pradesh, India.
Nanomedicine (Lond). 2024;19(21-22):1801-1819. doi: 10.1080/17435889.2024.2375193. Epub 2024 Jul 26.
Transethosomes, a fusion of transferosomes and ethosomes, combine the advantageous attributes of both vesicular systems to enhance deformability and skin permeation. While skin delivery is effective for drug transport, overcoming the skin barrier remains a significant challenge, particularly for plant-based products with poor permeability. Transethosomes offer a promising solution, but their low viscosity and retention on skin surfaces led to the development of transethosomal gels. These gels can entrap unstable and high molecular weight herbal extracts, fractions and bioactive compounds, facilitating enhanced drug delivery to the inner layers of the skin. This review focuses on the superior performance of transethosomes compared with conventional lipid-based nanovesicular systems, offering an advanced approach for transdermal delivery of plant-based drugs with improved permeability and stability.
转离子体，是传递体和醇质体的融合，兼具两种囊泡系统的优势特性，可增强变形性和皮肤渗透。 虽然皮肤传递对于药物输送是有效的，但克服皮肤屏障仍然是一个重大挑战，特别是对于具有较差渗透性的植物源性产品。 转离子体提供了一个有前途的解决方案，但它们在皮肤表面的低粘度和保留导致了转离子体凝胶的开发。 这些凝胶可以包封不稳定和高分子量的草药提取物、馏分和生物活性化合物，促进药物向皮肤内层的传递。 本文综述了转离子体与传统基于脂质的纳米囊泡系统相比的卓越性能，为具有改善的渗透性和稳定性的植物源性药物的经皮传递提供了一种先进的方法。
