Tieppo Antonio Martins, Tieppo Júlia Silva, Rivetti Luiz Antonio
Rehabilitation Service, School of Medical Sciences of Santa Casa de São Paulo, São Paulo 01221-020, Brazil.
Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.
Curr Issues Mol Biol. 2024 Jul 12;46(7):7339-7352. doi: 10.3390/cimb46070435.
Low back pain is a health problem that represents the greatest cause of years lived with disability. This research seeks to evaluate the bacterial composition of the intestinal microbiota of two similar groups: one with chronic low back pain (PG) and the control group (CG). Clinical data from 73 participants and bacterial genome sequencing data from stool samples were analyzed. There were 40 individuals in PG and 33 in CG, aged between 20 and 50 years and with a body mass index of up to 30 kg/m. Thus, the intragroup alpha diversity and intergroup beta diversity were analyzed. The significant results ( < 0.05) showed greater species richness in PG compared to CG. Additionally, a greater abundance of the species in PG was found along with 52 species with significantly different average relative abundances between groups (adjusted < 0.05), with 36 more abundant species in PG and 16 in CG. We are the first to unveil significant differences in the composition of the intestinal bacterial microbiota of individuals with chronic low back pain who are non-elderly, non-obese and without any other serious chronic diseases. It could be a reference for a possible intestinal bacterial microbiota signature in chronic low back pain.
腰痛是一个健康问题，是导致残疾生存年数的最大原因。本研究旨在评估两个相似组的肠道微生物群的细菌组成：一组为慢性腰痛患者（PG组），另一组为对照组（CG组）。分析了73名参与者的临床数据和粪便样本的细菌基因组测序数据。PG组有40人，CG组有33人，年龄在20至50岁之间，体重指数最高为30kg/m²。因此，对组内α多样性和组间β多样性进行了分析。显著结果（<0.05）表明，与CG组相比，PG组的物种丰富度更高。此外，在PG组中发现了该物种的丰度更高，同时还有52个物种在两组之间的平均相对丰度有显著差异（校正后<0.05），其中PG组有36个物种丰度更高，CG组有16个物种丰度更高。我们首次揭示了非老年、非肥胖且无任何其他严重慢性疾病的慢性腰痛患者肠道细菌微生物群组成的显著差异。这可能为慢性腰痛中可能的肠道细菌微生物群特征提供参考。
