Physical Medicine and Rehabilitation Service, Río Hortega University Hospital, 47012 Valladolid, Spain.
Toxins (Basel). 2024 Jul 16;16(7):320. doi: 10.3390/toxins16070320.
Hyperhidrosis (HH) is defined as the production of more sweat than is necessary for its thermoregulatory function, negatively affecting patients' quality of life and interfering with their social, work and family life. In this context, the aim of thisstudy was to evaluate the efficacy of two different doses of botulinum toxin type A (50 or 100 units) in each axilla in severe primary axillary hyperhidrosis. A descriptive, observational, cross-sectional and post-authorisation study was conducted onpatients referred to our department.Thirty-one patients with severe primary axillary hyperhidrosis were included, some of whom received more than one infiltration during the follow-up period, performing a total of 82 procedures. They were assigned by simple random sampling to two types of treatment: infiltration of 50 or 100 units (U) of botulinum toxin A per axilla.Hyperhidrosis severity was assessed using the Hyperhidrosis Disease Severity Scale (HDSS), and quality of life was assessed using the Dermatology Life Quality Index (DLQI) questionnaire. Onabotulinum toxin A infiltration reduced the severity of hyperhidrosis and improved the quality of life of the treated patients, with no significant differences between the two groups.
多汗症（HH）被定义为产生的汗液超过其热调节功能所需的量，从而对患者的生活质量产生负面影响，并干扰他们的社交、工作和家庭生活。在这种情况下，本研究旨在评估两种不同剂量的肉毒杆菌毒素 A（50 或 100 单位）在每个腋窝中对严重原发性腋窝多汗症的疗效。对我们部门转介的患者进行了描述性、观察性、横断面和上市后研究。共纳入 31 例严重原发性腋窝多汗症患者，其中一些患者在随访期间接受了多次浸润治疗，共进行了 82 次治疗。他们通过简单随机抽样分为两种治疗类型：每侧腋窝注射 50 或 100 单位（U）肉毒杆菌毒素 A。多汗症严重程度使用多汗症疾病严重程度量表（HDSS）进行评估，生活质量使用皮肤病生活质量指数（DLQI）问卷进行评估。肉毒杆菌毒素 A 浸润降低了多汗症的严重程度，改善了治疗患者的生活质量，两组之间没有显著差异。
