Pitiriga Vassiliki C, Campos Elsa, Bakalis John, Saroglou George, Tsakris Athanasios
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece.
Department of Internal Medicine, Metropolitan Hospital, 9 Ethnarchou Makariou Street, 18547 Athens, Greece.
Antibiotics (Basel). 2024 Jul 8;13(7):632. doi: 10.3390/antibiotics13070632.
Substantial knowledge gaps exist concerning the varying durations of peripherally inserted central catheter (PICC) placements that lead to either central line-associated bloodstream infection (CLABSI) or catheter colonization. We aimed to compare PICCs dwell time between patients who developed CLABSIs due to multidrug-resistant microorganisms (MDROs) and patients with catheter colonization by MDROs. Data from 86 patients admitted consecutively to a tertiary-care hospital from 2017 to 2020 were retrospectively analyzed. The mean dwell time was 25.73 ± 16.19 days in the PICC-CLABSI group and 16.36 ± 10.28 days in the PICC-colonization group ( = 0.002). The mean dwell time was 17.38 ± 9.5 days in the PICC-MDRO group and 22.48 ± 15.64 days in the PICC-non-MDRO group ( = 0.005). Within the PICC-CLABSI group, the mean dwell time for CLABSIs caused by MDROs was 21.50 ± 12.31 days, compared to 27.73 ± 16.98 days for CLABSIs caused by non-MDROs ( = 0.417). Within the PICC-colonization group, the mean dwell time was 15.55 ± 7.73 days in PICCs colonized by MDROs and 16.92 ± 11.85 days in PICCs colonized by non-MDROs ( = 0.124). The findings of the present study suggest that CLABSIs caused by MDROs in PICCs are associated with a shorter mean catheter dwell time compared to those caused by non-MDROs, underscoring the importance of considering infections by MDROs when evaluating PICC dwell times.
关于外周静脉穿刺中心静脉导管（PICC）留置不同时长导致中心静脉导管相关血流感染（CLABSI）或导管定植，目前存在相当大的知识空白。我们旨在比较因多重耐药微生物（MDRO）导致CLABSI的患者与MDRO导管定植患者之间的PICC留置时间。对2017年至2020年连续入住一家三级医院的86例患者的数据进行了回顾性分析。PICC-CLABSI组的平均留置时间为25.73±16.19天，PICC定植组为16.36±10.28天（P = 0.002）。PICC-MDRO组的平均留置时间为17.38±9.5天，PICC非MDRO组为22.48±15.64天（P = 0.005）。在PICC-CLABSI组中，MDRO引起的CLABSI平均留置时间为21.50±12.31天，而非MDRO引起的CLABSI为27.73±16.98天（P = 0.417）。在PICC定植组中，MDRO定植的PICC平均留置时间为15.55±7.73天，非MDRO定植的PICC为16.92±11.85天（P = 0.124）。本研究结果表明，与非MDRO引起的CLABSI相比，PICC中MDRO引起的CLABSI与较短的平均导管留置时间相关，这突出了在评估PICC留置时间时考虑MDRO感染的重要性。
