Schenk Alina, Popa Cosmin Octavian, Cojocaru Cristiana Manuela, Marian Ștefan, Maier Smaranda, Băjenaru Ovidiu Lucian, Bălașa Rodica
The Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania.
Department of Ethics and Social Science, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540142 Targu-Mures, Romania.
Behav Sci (Basel). 2024 Jul 21;14(7):620. doi: 10.3390/bs14070620.
Multiple sclerosis (MS) is one of the most debilitating neurodegenerative diseases in youth, significantly affecting all life domains. Therefore, a strong association between MS, depression and anxiety symptoms has been established. The objective of the present interventional one-group pretest-posttest study is to assess the feasibility of an online single-session intervention (SSI) based on a cognitive behavioral therapy protocol targeting depressive and anxiety symptoms, psychological mechanisms, fatigue and overall health status. In this pilot study, 31 patients with MS (M = 42 years, SD = 12.2) received the online CBT SSI. The impact of the intervention was assessed using validated instruments two weeks after the intervention and after a two-month follow-up period. Statistically significant effects were observed for the reduction of depression, with B -7.58, 95% CI (-12.84, -2.31) and < 0.01, and anxiety, with B = -15.17, 95% CI (-18.31, -12.02) and < 0.001, at post-test and follow-up screening. Additionally, positive outcomes were seen for irrational beliefs at post-test, with B = -25.86, 95% CI (-46.10, -5.61), along with negative automatic thoughts, with B = -4.47, 95% CI (-10.65, 1.71), which were preserved at follow-up. Despite the health status also improving, no significant changes were observed for dysfunctional attitudes and fatigue. This research proves that the online CBT SSI was efficient for decreasing mild to moderate symptoms of depression and anxiety and reducing the intensity of dysfunctional psychological mechanisms in our sample.
多发性硬化症（MS）是青年群体中最使人衰弱的神经退行性疾病之一，严重影响生活的各个方面。因此，MS与抑郁和焦虑症状之间已确立了紧密联系。本干预性单组前后测研究的目的是评估基于认知行为疗法方案的在线单节干预（SSI）针对抑郁和焦虑症状、心理机制、疲劳及整体健康状况的可行性。在这项试点研究中，31名MS患者（M = 42岁，SD = 12.2）接受了在线认知行为疗法SSI。干预两周后以及两个月的随访期后，使用经过验证的工具评估干预效果。在测试后和随访筛查中，观察到抑郁症状减轻有统计学显著效果，B = -7.58，95%置信区间（-12.84，-2.31），P < 0.01；焦虑症状减轻也有统计学显著效果，B = -15.17，95%置信区间（-18.31，-12.02），P < 0.001。此外，测试后在非理性信念方面有积极结果，B = -25.86，95%置信区间（-46.10，-5.61），消极自动思维方面也有积极结果，B = -4.47，95%置信区间（-10.65，1.71），这些结果在随访时得以保持。尽管健康状况也有所改善，但功能失调态度和疲劳方面未观察到显著变化。这项研究证明，在线认知行为疗法SSI在减轻我们样本中轻度至中度抑郁和焦虑症状以及降低功能失调心理机制强度方面是有效的。
