Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran.
Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
Prog Biophys Mol Biol. 2024 Oct;192:1-10. doi: 10.1016/j.pbiomolbio.2024.07.006. Epub 2024 Jul 27.
Diabetic foot ulcers, as one of the chronic wounds, are a serious challenge in the global healthcare system which have shown notable growth in recent years. DFU is associated with impairment in various stages of wound healing, including angiogenesis. Aberrant expression of microRNAs (miRNAs) involved in the disruption of the balance between angiogenic and anti-angiogenic factors, plays a crucial role in angiogenesis dysfunction. Alteration in the expression of angiomiRNAs (angiomiRs) have the potential to function as biomarkers in chronic wounds. Additionally, considering the rising importance of therapeutic RNAs, there is potential for utilizing angiomiRs in wound healing to induce angiogenesis. This review aims to explore angiogenesis in chronic wounds and investigate the mechanisms mediated by pro- and anti-angiomiRs in the context of diabetic foot ulcers.
糖尿病足溃疡是全球医疗体系面临的严峻挑战之一，近年来其发病率显著上升。糖尿病足溃疡在创伤愈合的各个阶段都存在功能障碍，包括血管生成。涉及血管生成和抗血管生成因子平衡破坏的 microRNAs（miRNAs）异常表达在血管生成功能障碍中发挥关键作用。angiomiRNAs（angiomiRs）表达的改变有可能作为慢性创面的生物标志物。此外，鉴于治疗性 RNA 的重要性不断上升，利用 angiomiRs 诱导血管生成促进创面愈合具有一定的潜力。本综述旨在探讨慢性创面的血管生成，并研究糖尿病足溃疡中促血管生成和抗血管生成 angiomiRs 介导的机制。
