Division of Pulmonary Medicine, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, 4401 Penn Avenue, AOB Suite 3300, Pittsburgh, PA 15224, USA.
Division of Pulmonary Medicine, NYU Grossman School of Medicine, Hassenfeld Children's Hospital, 240 East 38th Street, 14th Floor, New York, NY 10016, USA.
Clin Chest Med. 2024 Sep;45(3):761-769. doi: 10.1016/j.ccm.2024.02.023.
Pediatric lung transplantation for pulmonary vascular diseases has seen notable advancements and trends. Medical therapies, surgical options, and bridging techniques like extracorporeal membrane oxygenation and different forms of transplants have expanded treatment possibilities. Current challenges include ensuring patient adherence to post-transplant therapies, addressing complications like primary graft dysfunction and rejection, and conducting further research in less common conditions like pulmonary veno-occlusive disease and pulmonary vein stenosis. In this review article, the authors will explore the advancements, emerging trends, and persistent challenges in pediatric lung transplantation for pulmonary vascular diseases.
儿科肺移植治疗肺血管疾病取得了显著进展和趋势。医学治疗、手术选择以及体外膜氧合等桥接技术和不同形式的移植都扩大了治疗可能性。目前的挑战包括确保患者坚持接受移植后治疗、解决原发性移植物功能障碍和排斥等并发症,以及在肺静脉闭塞病和肺静脉狭窄等较少见疾病中开展进一步研究。在这篇综述文章中,作者将探讨儿科肺移植治疗肺血管疾病的进展、新兴趋势和持续挑战。