Kwapiszewska Karina
Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw 01-224, Poland.
ACS Phys Chem Au. 2024 Apr 6;4(4):314-321. doi: 10.1021/acsphyschemau.3c00079. eCollection 2024 Jul 24.
The vast majority of chemical processes that govern our lives occur within living cells. At the core of every life process, such as gene expression or metabolism, are chemical reactions that follow the fundamental laws of chemical kinetics and thermodynamics. Understanding these reactions and the factors that govern them is particularly important for the life sciences. The physicochemical environment inside cells, which can vary between cells and organisms, significantly impacts various biochemical reactions and increases the extent of population heterogeneity. This paper discusses using physical chemistry approaches for biological studies, including methods for studying reactions inside cells and monitoring their conditions. The potential for development in this field and possible new research areas are highlighted. By applying physical chemistry methodology to biochemistry , we may gain new insights into biology, potentially leading to new ways of controlling biochemical reactions.
支配我们生活的绝大多数化学过程都发生在活细胞内。在每一个生命过程的核心，如基因表达或新陈代谢，都是遵循化学动力学和热力学基本定律的化学反应。理解这些反应及其控制因素对生命科学尤为重要。细胞内部的物理化学环境在不同细胞和生物体之间可能有所不同，它会显著影响各种生化反应，并增加群体异质性的程度。本文讨论了使用物理化学方法进行生物学研究，包括研究细胞内反应及其条件监测的方法。文中强调了该领域的发展潜力和可能的新研究领域。通过将物理化学方法应用于生物化学，我们可能会对生物学有新的见解，从而有可能找到控制生化反应的新方法。
