Cai Dan, Chen Gui-Lin, Wang Ting, Zhang Kun-He
Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China.
Jiangxi Institute of Gastroenterology and Hepatology, Nanchang 330006, Jiangxi Province, China.
World J Clin Cases. 2024 Jul 26;12(21):4726-4741. doi: 10.12998/wjcc.v12.i21.4726.
BACKGROUND: Malignant tumors are one of the leading causes of death worldwide, imposing a substantial economic and social burden. Early detection is the key to improving cure rates and reducing mortality rates, which requires the development of sensitive early detection technologies. Signal amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from researchers. AIM: To investigate the current research status, developmental trajectories, and hotspots in signal amplification for aptamer-based tumor detection through bibliometric analysis. METHODS: English publications pertaining to signal amplification in aptamer-based tumor detection were retrieved from the Web of Science Core Collection database. VOSviewer and CiteSpace software were employed to analyze various information within this field, including countries, institutions, authors, co-cited authors, journals, co-cited journals, cited references, and keywords. RESULTS: A total of 757 publications were included in this study. China accounted for 85.47% of all publications, with Nanjing University (China) emerging as the institution with the highest publication output. The most influential authors and journals were Hasanzadeh M. from Iran and "", respectively. Exosomes and carcinoembryonic antigen (CEA) stood out as the most researched tumor-related molecules. Currently, the predominant signal amplification technique, nanomaterial, and signal transduction method were identified as hybridization chain reactions, gold nanoparticles, and electrochemical methods, respectively. Over the past 3 years, exosomes, CEA, electrochemical biosensors, and nanosheets have emerged as research hotspots, exhibiting a robust burst of intensity. CONCLUSION: This study is the first bibliometric analysis of literature on signal amplification in aptamer-based tumor detection and elucidates the current status, hotspots, and prospective research directions within this realm. Additionally, it provides an important reference for researchers.
背景：恶性肿瘤是全球主要死因之一，带来了巨大的经济和社会负担。早期检测是提高治愈率和降低死亡率的关键，这需要开发灵敏的早期检测技术。信号放大技术在基于适配体的肿瘤早期检测中起着至关重要的作用，越来越受到研究人员的关注。 目的：通过文献计量分析，探讨基于适配体的肿瘤检测中信号放大的研究现状、发展轨迹和热点。 方法：从Web of Science核心合集数据库中检索有关基于适配体的肿瘤检测中信号放大的英文出版物。使用VOSviewer和CiteSpace软件分析该领域内的各种信息，包括国家、机构、作者、共被引作者、期刊、共被引期刊、被引参考文献和关键词。 结果：本研究共纳入757篇出版物。中国占所有出版物的85.47%，南京大学（中国）是发表量最高的机构。最具影响力的作者和期刊分别是来自伊朗的Hasanzadeh M.和《》。外泌体和癌胚抗原（CEA）是研究最多的肿瘤相关分子。目前，主要的信号放大技术、纳米材料和信号转导方法分别被确定为杂交链式反应、金纳米颗粒和电化学方法。在过去3年中，外泌体、CEA、电化学生物传感器和纳米片已成为研究热点，呈现出强劲的强度爆发。 结论：本研究是对基于适配体的肿瘤检测中信号放大文献的首次文献计量分析，阐明了该领域的现状、热点和前瞻性研究方向。此外，它为研究人员提供了重要参考。
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