光氧化还原催化下1,7-烯炔与叶立德和水的立体选择性三组分碳环化反应
Stereoselective Three-Component Carbocyclization of 1,7-Enynes with Sulfoxonium Ylides and Water under Photoredox Catalysis.
作者信息
Xian Ning, Yin Jiang, Ji Xiaochen, Deng Guo-Jun, Huang Huawen
机构信息
College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, China.
出版信息
Org Lett. 2024 Aug 9;26(31):6736-6741. doi: 10.1021/acs.orglett.4c02423. Epub 2024 Jul 29.
A visible-light-induced photoredox three-component carbocyclization reaction of 1,7-enynes with sulfoxonium ylides and water is reported. The protocol provides a facile entry to structurally valuable highly functionalized cyclopenta[]quinoline scaffolds in a highly chemoselective and stereoselective manner. Salient features of this method include facile redox-neutral conditions, no requirement of base or other additive, and good functional-group tolerance.
报道了一种可见光诱导的1,7-烯炔与亚砜叶立德和水的光氧化还原三组分碳环化反应。该方法以高度化学选择性和立体选择性的方式为结构上有价值的高度官能团化的环戊并[ ]喹啉支架提供了一条便捷的途径。该方法的显著特点包括温和的氧化还原中性条件、无需碱或其他添加剂以及良好的官能团耐受性。
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