School of Medicine and Health, Wuhan Polytechnic University, Wuhan 430023, Hubei, China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
Toxicol Appl Pharmacol. 2024 Sep;490:117044. doi: 10.1016/j.taap.2024.117044. Epub 2024 Jul 27.
Many studies have reported that prenatal exposure to Per- and Polyfluoroalkyl Substances (PFASs) can disrupt immune function. However, little is known about the effects of PFASs on immune molecules. The study analyzed the association between prenatal exposure to mixed and single PFASs and plasma immune molecules in three-year-old children.
Ten PFASs were measured in umbilical cord serum, while peripheral blood samples were collected at age three to measure immune molecules. Associations between exposure to individual and combined PFASs and immune molecules were analyzed using Generalized Linear Models and Weighted Quantile Sum (WQS) regression.
(1) Interleukin-4 (IL-4) increased by 23.85% (95% CI:2.99,48.94) with each doubling of Perfluorooctanoic Acid (PFOA), and Interleukin-6 (IL-6) increased by 39.07% (95%CI:4.06,85.86) with Perfluorotridecanoic Acid (PFTrDA). Elevated PFOA and Perfluorononanoic Acid (PFNA) were correlated with increases of 34.06% (95% CI: 6.41, 70.28) and 24.41% (95% CI: 0.99, 53.27) in Eotaxin-3, respectively. Additionally, the doubling of Perfluorohexane Sulfonic Acid (PFHxS) was associated with a 9.51% decrease in Periostin (95% CI: -17.84, -0.33). (2) The WQS analysis revealed that mixed PFASs were associated with increased IL-6 (β = 0.37, 95%CI:0.04,0.69), mainly driven by PFTrDA, PFNA, and 8:2 Chlorinated Perfluoroethyl Sulfonamide (8:2 Cl-PFESA). Moreover, mixed PFASs were linked to an increase in Eotaxin-3 (β = 0.32, 95% CI: 0.09,0.55), primarily influenced by PFOA, PFTrDA, and Perfluorododecanoic Acid (PFDoDA).
Prenatal PFASs exposure significantly alters the levels of immune molecules in three-year-old children, highlighting the importance of understanding environmental impacts on early immune development.
许多研究报告称，产前暴露于全氟和多氟烷基物质（PFASs）会破坏免疫功能。然而，对于 PFASs 对免疫分子的影响知之甚少。本研究分析了产前混合和单一 PFASs 暴露与三岁儿童血浆免疫分子之间的关系。
在脐带血清中测量了十种 PFASs，而在三岁时采集外周血样以测量免疫分子。使用广义线性模型和加权分位数总和（WQS）回归分析了个体和联合 PFASs 与免疫分子之间的关联。
（1）随着全氟辛酸（PFOA）的加倍，白细胞介素-4（IL-4）增加了 23.85%（95%CI：2.99，48.94），白细胞介素-6（IL-6）随着全氟十三酸（PFTrDA）的增加增加了 39.07%（95%CI：4.06，85.86）。升高的 PFOA 和全氟壬酸（PFNA）分别与 Eotaxin-3 的增加 34.06%（95% CI：6.41，70.28）和 24.41%（95% CI：0.99，53.27）相关。此外，全氟己烷磺酸（PFHxS）的加倍与 Periostin 减少 9.51%（95%CI：-17.84，-0.33）相关。（2）WQS 分析表明，混合 PFASs 与白细胞介素-6（β=0.37，95%CI：0.04，0.69）的增加有关，主要由 PFTrDA、PFNA 和 8:2 氯代全氟乙磺酸（8:2 Cl-PFESA）驱动。此外，混合 PFASs 与 Eotaxin-3 的增加有关（β=0.32，95%CI：0.09，0.55），主要受 PFOA、PFTrDA 和全氟十二烷酸（PFDoDA）影响。
产前 PFASs 暴露显著改变了三岁儿童免疫分子的水平，强调了了解环境对早期免疫发育影响的重要性。
