Sajeev Anjana, BharathwajChetty Bandari, Manickasamy Mukesh Kumar, Alqahtani Mohammed S, Abbas Mohamed, Shakibaei Mehdi, Sethi Gautam, Ma Zhaowu, Kunnumakkara Ajaikumar B
Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, Assam, India.
Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Front Oncol. 2024 Jul 15;14:1383939. doi: 10.3389/fonc.2024.1383939. eCollection 2024.
Ovarian cancer (OVC) is one of the most common causes of cancer-related deaths in women worldwide. Despite advancements in detection and therapy, the prognosis of OVC remains poor due to late diagnosis and the lack of effective therapeutic options at advanced stages. Therefore, a better understanding of the biology underlying OVC is essential for the development of effective strategies for early detection and targeted therapies. Nuclear receptors (NRs) are a superfamily of 48 transcription factors that, upon binding to their specific ligand, play a vital role in regulating various cellular processes such as growth, development, metabolism, and homeostasis. Accumulating evidence from several studies has shown that their aberrant expression is associated with multiple human diseases. Numerous NRs have shown significant effects in the development of various cancers, including OVC. This review summarizes the recent findings on the role of NRs in OVC, as well as their potential as prognostic and therapeutic markers. Further, the basic structure and signaling mechanism of NRs have also been discussed briefly. Moreover, this review highlights their cellular and molecular mechanisms in chemoresistance and chemosensitization. Further, the clinical trials targeting NRs for the treatment of OVC have also been discussed.
卵巢癌（OVC）是全球女性癌症相关死亡的最常见原因之一。尽管在检测和治疗方面取得了进展，但由于诊断较晚以及晚期缺乏有效的治疗选择，OVC的预后仍然很差。因此，更好地了解OVC的生物学特性对于制定早期检测和靶向治疗的有效策略至关重要。核受体（NRs）是一个由48种转录因子组成的超家族，它们在与特定配体结合后，在调节各种细胞过程（如生长、发育、代谢和体内平衡）中发挥着至关重要的作用。多项研究积累的证据表明，它们的异常表达与多种人类疾病有关。许多NRs在包括OVC在内的各种癌症的发生发展中都显示出显著作用。本综述总结了NRs在OVC中的作用的最新发现，以及它们作为预后和治疗标志物的潜力。此外，还简要讨论了NRs的基本结构和信号传导机制。此外，本综述还重点介绍了它们在化疗耐药和化疗增敏中的细胞和分子机制。此外，还讨论了针对NRs治疗OVC的临床试验。
