Coates G, Dolovich M, Koehler D, Newhouse M T
Clin Nucl Med. 1985 Dec;10(12):835-8. doi: 10.1097/00003072-198512000-00001.
We have compared the distribution in the lungs of submicronic aerosols of either Tc-99m sulfur colloid or Tc-99m DTPA immediately after inhalation with the distribution 20 minutes later in 83 patients. Thirty-two of the 83 patients were active smokers. Of the 28 smokers who received Tc-99m DTPA aerosol, the total lung count fell by a mean of 27 +/- 14% between the 0 and 20 minute image. Eleven of these patients also had a major change in distribution of isotope during this time. In the nonsmoking patients total lung counts from Tc-99m DTPA fell by only 16 +/- 8% and none had a major change in distribution pattern. None of the smoking or non-smoking patients who received Tc-99m sulfur colloid had a significant change in count rate or distribution pattern over 20 minutes. The effects on the ventilation images of these rapid changes in count rate and distribution pattern after Tc-99m DTPA aerosol can be minimized by completing the ventilation study as quickly as possible after inhaling Tc-99m DTPA or by using a nondiffusible agent such as Tc-99m sulfur colloid.
我们比较了83例患者吸入后即刻Tc-99m硫胶体或Tc-99m二乙三胺五乙酸（DTPA）亚微米气溶胶在肺内的分布与20分钟后的分布情况。83例患者中有32例为现吸烟者。在28例接受Tc-99m DTPA气溶胶的吸烟者中，0分钟和20分钟影像之间全肺计数平均下降了27±14%。其中11例患者在此期间同位素分布也有重大变化。在非吸烟患者中，Tc-99m DTPA的全肺计数仅下降了16±8%，且无人分布模式有重大变化。接受Tc-99m硫胶体的吸烟或非吸烟患者在20分钟内计数率或分布模式均无显著变化。吸入Tc-99m DTPA后计数率和分布模式的这些快速变化对通气影像的影响，可通过在吸入Tc-99m DTPA后尽快完成通气研究或使用不可扩散的制剂如Tc-99m硫胶体来最小化。
