Wang Yan, Zha Yan, Liu Lin, Liao Ang, Dong Ziqiang, Roberts Neil, Li Yaying
Department of Nuclear Medicine, Guizhou Provincial People's Hospital, Affiliated Hospital of Guizhou University, Guiyang 550002, Guizhou Province, China.
Departnent of Nephrology, Guizhou Provincial People's Hospital, Affiliated Hospital of Guizhou University, Guiyang 550002, Guizhou Province, China.
J Transl Int Med. 2023 Mar 19;12(3):215-224. doi: 10.2478/jtim-2022-0066. eCollection 2024 Jun.
Gouty arthritis, often referred to simply as gout, is a disorder of purine metabolism characterized by the deposition of monosodium urate monohydrate (MSU) crystals in multiple systems and organs, especially in joints and their surrounding soft tissue. Gout is a treatable chronic disease, and the main strategy for effective management is to reverse the deposition of MSU crystals by uric acid reduction, and to prevent gout attacks, tophi deposition and complications, and thereby improve the quality of life. However, the frequent association of gout with other conditions such as hypertension, obesity, cardiovascular disease, diabetes, dyslipidemia, chronic kidney disease (CKD) and kidney stones can complicate the treatment of gout and lead to premature death. Here, we review the use of medical imaging techniques for studying gouty arthritis with special interest in the potential role of single photon emission computed tomography (SPECT)/computed tomography (CT) in the clinical management of gout and complications (., chronic kidney disease and cardiovascular disease).
痛风性关节炎，通常简称为痛风，是一种嘌呤代谢紊乱疾病，其特征是单水尿酸钠（MSU）晶体沉积于多个系统和器官，尤其是关节及其周围软组织。痛风是一种可治疗的慢性疾病，有效管理的主要策略是通过降低尿酸来逆转MSU晶体的沉积，并预防痛风发作、痛风石沉积及并发症，从而提高生活质量。然而，痛风常与其他病症如高血压、肥胖、心血管疾病、糖尿病、血脂异常、慢性肾脏病（CKD）和肾结石相关，这会使痛风的治疗复杂化并导致过早死亡。在此，我们综述医学成像技术在研究痛风性关节炎中的应用，特别关注单光子发射计算机断层扫描（SPECT）/计算机断层扫描（CT）在痛风及其并发症（如慢性肾脏病和心血管疾病）临床管理中的潜在作用。
