Department of Nuclear Medicine, Iatropolis Medical Group, Athens, .
Department of Nuclear Medicine, Theageneio Cancer Center, Thessaloniki, .
Nucl Med Commun. 2024 Nov 1;45(11):924-930. doi: 10.1097/MNM.0000000000001881. Epub 2024 Jul 30.
In this prospective study, we investigated the correlation between prostate-specific antigen (PSA) levels in the blood of patients with prostate cancer in biochemical recurrence after radical treatment with the semiquantitative parameters standard uptake value maximum (SUV max ) and the total metabolic tumor volume (TMTV) in the metastatic foci depicted in 18F-prostate-specific membrane antigen (PSMA)-1007 and 18F-choline PET/computed tomography (CT) imaging.
We prospectively examined 104 patients with biochemical relapse of prostate cancer after primary definitive treatment. All patients underwent one 18F-PSMA-1007 and one 18F-choline PET/CT examination in randomized order within a time frame of 10 days and were followed for at least 6 months (182 ± 10 days). The semiquantitative parameters of SUV max and metabolic tumor volume (MTV) of each neoplastic lesion in PET/CT imaging were calculated, and further summation of each MTV value was done to calculate the TMTV.
According to the Spearman correlation analysis, a positive correlation was found between PSA levels and SUV max and TMTV scores in the metastatic foci of 18F-PSMA-1007 PET/CT ( r = 0.24 and 0.35, respectively; P < 0.05) and SUV max in the lesions of 18F-choline PET/CT ( r = 0.28; P < 0.0239). However, a positive but NS correlation was demonstrated between values of PSA and TMTV for each lesion in the 18F-choline PET/CT study ( r = 0.22; P = 0.0795). The detection rate of the different PSA levels with a cutoff of 1 ng/ml was higher for 18F-PSMA-1007 than 18F-choline.
In biochemical relapse patients there is a positive correlation between PSA levels in the blood and the semiquantitative parameters SUV max and TMTV of the metastatic foci in the 18F-PSMA-1007 and 18F-Choline PET/CT imaging.
在这项前瞻性研究中，我们调查了根治性治疗后生化复发的前列腺癌患者血液中前列腺特异性抗原（PSA）水平与 18F-前列腺特异性膜抗原（PSMA）-1007 和 18F-胆碱 PET/CT 成像中转移性病灶的半定量参数最大标准摄取值（SUVmax）和总代谢肿瘤体积（TMTV）之间的相关性。
我们前瞻性地检查了 104 例原发性确定性治疗后生化复发的前列腺癌患者。所有患者在 10 天的时间内以随机顺序接受一次 18F-PSMA-1007 和一次 18F-胆碱 PET/CT 检查，并至少随访 6 个月（182±10 天）。计算 PET/CT 成像中每个肿瘤病变的 SUVmax 和代谢肿瘤体积（MTV）的半定量参数，并对每个 MTV 值进行求和以计算 TMTV。
根据 Spearman 相关分析，发现 18F-PSMA-1007 PET/CT 中转移性病灶的 PSA 水平与 SUVmax 和 TMTV 评分呈正相关（r=0.24 和 0.35，分别；P<0.05），而 18F-胆碱 PET/CT 中病灶的 SUVmax 也呈正相关（r=0.28；P<0.0239）。然而，18F-胆碱 PET/CT 研究中每个病灶的 PSA 值与 TMTV 值之间呈正相关但无统计学意义（r=0.22；P=0.0795）。对于 PSA 水平为 1ng/ml 的不同截断值，18F-PSMA-1007 的检测率高于 18F-胆碱。
在生化复发患者中，血液中 PSA 水平与 18F-PSMA-1007 和 18F-胆碱 PET/CT 成像中转移性病灶的半定量参数 SUVmax 和 TMTV 之间存在正相关。
