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肺炎:一例病例报告并文献复习。

pneumonia: a case report and literature review.

机构信息

Department of Infectious Diseases, The First People's Hospital of Kunshan, Kunshan, Jiangsu, China.

Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

出版信息

Postgrad Med. 2024 Aug;136(6):678-682. doi: 10.1080/00325481.2024.2385888. Epub 2024 Jul 31.

Abstract

BACKGROUND

Legionella maceachernii pneumonia is a severe respiratory infection with low incidence but high mortality. However, the optimal treatment for this disease remains unclear. We report a case of successful treatment of Legionella maceachernii pneumonia, which is the first report of such a case in China.

CASE PRESENTATION

An 87-year-old man with concomitant chronic obstructive pulmonary disease, liver cirrhosis, and history of left nephrectomy was diagnosed with Legionella maceachernii pneumonia using Dano-seq pathogen metagenomic testing. After two weeks of treatment with cefoperazone/sulbactam combined with quinolone antibiotics, the patient showed improvement and was discharged. The patient continued to take oral quinolone antibiotics for one week after discharge and recovered during outpatient follow-up.

CONCLUSIONS

Dano-seq pathogen metagenomic testing can rapidly diagnose Legionella maceachernii pneumonia, and taking quinolone antibiotics is an effective treatment.

摘要

背景

嗜肺军团菌性肺炎是一种严重的呼吸道感染,发病率低但死亡率高。然而,这种疾病的最佳治疗方法仍不清楚。我们报告了一例嗜肺军团菌性肺炎成功治疗的病例,这是中国首例此类病例报告。

病例介绍

一名 87 岁男性,患有慢性阻塞性肺疾病、肝硬化,并有左肾切除术史,通过 Dano-seq 病原体宏基因组检测诊断为嗜肺军团菌性肺炎。经过两周的头孢哌酮/舒巴坦联合喹诺酮类抗生素治疗后,患者病情改善并出院。出院后,患者继续口服喹诺酮类抗生素一周,并在门诊随访中康复。

结论

Dano-seq 病原体宏基因组检测可快速诊断嗜肺军团菌性肺炎,使用喹诺酮类抗生素是一种有效的治疗方法。

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