Liu Zhihao, Dong Lei, Shen Geng, Sun Yangyang, Liu Yuting, Mei Jiarong, Jia Jia, Fan Fangfang, Wang Wenye, Huang Wei, Li Jianping
Department of Cardiology, Peking University First Hospital, Beijing, China.
Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, China.
Front Cardiovasc Med. 2024 Jul 17;11:1397422. doi: 10.3389/fcvm.2024.1397422. eCollection 2024.
The associations of neutrophil-percentage-to-albumin ratio (NPAR) level with all-cause and cardiovascular disease (CVD)-cause mortality among patients with hypertension remain unclear. This study aims to investigate the associations of NPAR level with all-cause and CVD-cause mortality among patients with hypertension.
This prospective cohort study included 8,990 patients with hypertension who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2010. Multivariable Cox proportional hazards regression models were used to compute hazard ratios and 95% CIs for the associations of NPAR level with all-cause mortality and CVD-cause mortality. Restricted cubic spline analyses were used to examine the nonlinear association of NPAR level with all-cause mortality and CVD-cause mortality.
This cohort study included data from 8,990 participants in analysis. During 104,474 person-years of follow-up, 3,069 all-cause deaths and 1,449 CVD-cause deaths were documented. Nonlinear associations were observed for NPAR levels with risk of all-cause mortality and CVD-cause mortality among patients with hypertension. Compared with participants in T1 of NPAR, there was a significantly increased risk of all-cause mortality and CVD-cause mortality for participants in both T2 and T3 in the fully adjusted model (model 3). The corresponding HRs for all-cause mortality were 1.10 (95% CI, 0.98-1.22) and 1.63 (95% CI, 1.45-1.82). The corresponding HRs for CVD-cause mortality were 1.10 (95% CI, 0.99-1.23) and 1.63 (95% CI, 1.46-1.81).
Elevated NPAR level was significantly associated with an increased risk of all-cause and CVD-cause mortality in adults with hypertension. NPAR may be clinically useful for predicting long-term health outcomes and mortality in hypertensive population.
高血压患者中性粒细胞百分比与白蛋白比值（NPAR）水平与全因死亡率和心血管疾病（CVD）所致死亡率之间的关联尚不清楚。本研究旨在探讨高血压患者NPAR水平与全因死亡率和CVD所致死亡率之间的关联。
这项前瞻性队列研究纳入了1999年至2010年参加美国国家健康与营养检查调查（NHANES）的8990例高血压患者。采用多变量Cox比例风险回归模型计算NPAR水平与全因死亡率和CVD所致死亡率之间关联的风险比和95%置信区间。采用受限立方样条分析来检验NPAR水平与全因死亡率和CVD所致死亡率之间的非线性关联。
该队列研究纳入了8990名参与者的数据进行分析。在104474人年的随访期间，记录了3069例全因死亡和1449例CVD所致死亡。在高血压患者中，观察到NPAR水平与全因死亡率和CVD所致死亡率风险之间存在非线性关联。在完全调整模型（模型3）中，与NPAR的T1组参与者相比，T2组和T3组参与者的全因死亡率和CVD所致死亡率风险显著增加。全因死亡率的相应风险比分别为1.10（95%置信区间，0.98 - 1.22）和1.63（95%置信区间，1.45 - 1.82）。CVD所致死亡率的相应风险比分别为1.10（95%置信区间，0.99 - 1.23）和1.63（95%置信区间，1.46 - 1.81）。
NPAR水平升高与高血压成人全因死亡率和CVD所致死亡率风险增加显著相关。NPAR在临床上可能有助于预测高血压人群的长期健康结局和死亡率。
