系统评价和荟萃分析经颅直流电刺激（tDCS）治疗轻度认知障碍和阿尔茨海默病患者整体认知的效果。
Systematic review and meta-analysis of transcranial direct current stimulation (tDCS) for global cognition in mild cognitive impairment and Alzheimer's disease.
机构信息
Nursing College, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, PR China.
Nursing College, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, PR China.
出版信息
Geriatr Nurs. 2024 Sep-Oct;59:261-270. doi: 10.1016/j.gerinurse.2024.07.013. Epub 2024 Jul 31.
OBJECTIVE
To systematically assess the effectiveness of transcranial direct current stimulation (tDCS) on global cognition in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
DATA SOURCES
Ten databases were retrieved for pertinent Chinese and English studies published up until February 2023.
DATA EXTRACTION
Two researchers independently selected the literature, extracted the data, evaluated using the Cochrane Collaboration's quality criteria, and then cross-checked. Meta-analysis was performed using RevMan 5.4.
RESULTS
22 studies involving 1074 patients were included. Compared with the control group received the interventions such as pharmacotherapy, cognitive stimulation, et al., with/without sham-tDCS, while the experiment group received tDCS added to the interventions of the control group. The meta-analysis found that tDCS increased MMSE, MoCA, MODA scores and reduced the P300 latency scores (all P < 0.05).
CONCLUSION
The tDCS can ameliorate the global cognition of patients with MCI and AD, and it has a better rehabilitation effect than non-tDCS or sham-tDCS.
目的
系统评估经颅直流电刺激（tDCS）对轻度认知障碍（MCI）和阿尔茨海默病（AD）患者整体认知的疗效。
资料来源
检索了截至 2023 年 2 月发表的相关中文和英文研究的 10 个数据库。
资料提取
两名研究人员独立选择文献、提取数据，使用 Cochrane 协作组的质量标准进行评估，然后交叉核对。使用 RevMan 5.4 进行荟萃分析。
结果
纳入了 22 项研究，共涉及 1074 名患者。与接受药物治疗、认知刺激等干预措施的对照组相比，实验组接受了 tDCS 联合对照组干预措施。荟萃分析发现 tDCS 可提高 MMSE、MoCA、MODA 评分，降低 P300 潜伏期评分（均 P < 0.05）。
结论
tDCS 可改善 MCI 和 AD 患者的整体认知，其康复效果优于非 tDCS 或假 tDCS。
Zotero 插件