Kim Andrew H, Hostin Richard A, Yeramaneni Samrat, Gum Jeffrey L, Nayak Pratibha, Line Breton G, Bess Shay, Passias Peter G, Hamilton D Kojo, Gupta Munish C, Smith Justin S, Lafage Renaud, Diebo Bassel G, Lafage Virginie, Klineberg Eric O, Daniels Alan H, Protopsaltis Themistocles S, Schwab Frank J, Shaffrey Christopher I, Ames Christopher P, Burton Douglas C, Kebaish Khaled M
Department of Orthopaedic Surgery, The Johns Hopkins University, 601 N Caroline St. 5th Floor, Baltimore, MD, 21205, USA.
Department of Orthopaedic Surgery, Baylor Scoliosis Center, Plano, TX, USA.
Spine Deform. 2024 Nov;12(6):1783-1791. doi: 10.1007/s43390-024-00919-7. Epub 2024 Aug 2.
Adult spinal deformity (ASD) patients with sagittal plane deformity (N) or structural lumbar/thoraco-lumbar (TL) curves can be treated with fusions stopping at the TL junction or extending to the upper thoracic (UT) spine. This study evaluates the impact on cost/cumulative quality-adjusted life year (QALY) in patients treated with TL vs UT fusion.
ASD patients with > 4-level fusion and 2-year follow-up were included. Index and total episode-of-care costs were estimated using average itemized direct costs obtained from hospital records. Cumulative QALY gained were calculated from preoperative to 2-year postoperative change in Short Form Six-Dimension (SF-6D) scores. The TL and UT groups comprised patients with upper instrumented vertebrae (UIV) at T9-T12 and T2-T5, respectively.
Of 566 patients with type N or L curves, mean age was 63.2 ± 12.1 years, 72% were female and 93% Caucasians. Patients in the TL group had better sagittal vertical axis (7.3 ± 6.9 vs. 9.2 ± 8.1 cm, p = 0.01), lower surgical invasiveness (- 30; p < 0.001), and shorter OR time (- 35 min; p = 0.01). Index and total costs were 20% lower in the TL than in the UT group (p < 0.001). Cost/QALY was 65% lower (492,174.6 vs. 963,391.4), and 2-year QALY gain was 40% higher, in the TL than UT group (0.15 vs. 0.10; p = 0.02). Multivariate model showed TL fusions had lower total cost (p = 0.001) and higher QALY gain (p = 0.03) than UT fusions.
In Schwab type N or L curves, TL fusions showed lower 2-year cost and improved QALY gain without increased reoperation rates or length of stay than UT fusions.
III.
患有矢状面畸形(N型)或结构性腰椎/胸腰段(TL)曲线的成人脊柱畸形(ASD)患者可通过融合手术进行治疗,融合范围可止于胸腰段交界处或延伸至上胸椎(UT)脊柱。本研究评估了胸腰段融合术与上胸椎融合术对患者成本/累积质量调整生命年(QALY)的影响。
纳入接受超过4节段融合且随访2年的ASD患者。使用从医院记录中获取的平均逐项直接成本来估算索引成本和总护理期间成本。累积获得的QALY是根据术前至术后2年的简短六维健康调查(SF - 6D)评分变化计算得出的。胸腰段组和上胸椎组分别包括上固定椎(UIV)位于T9 - T12和T2 - T5的患者。
在566例N型或L型曲线患者中,平均年龄为63.2±12.1岁,72%为女性,93%为白种人。胸腰段组患者的矢状垂直轴情况更好(7.3±6.9 vs. 9.2±8.1厘米,p = 0.01),手术侵袭性更低(-30;p < 0.001),手术时间更短(-35分钟;p = 0.01)。胸腰段组的索引成本和总成本比上胸椎组低20%(p < 0.001)。胸腰段组的成本/QALY比上胸椎组低65%(492,174.6 vs. 963,391.4),且2年QALY增益比上胸椎组高40%(0.15 vs. 0.10;p = 0.02)。多变量模型显示,与上胸椎融合术相比,胸腰段融合术的总成本更低(p = 0.001),QALY增益更高(p = 0.03)。
在施瓦布N型或L型曲线中,胸腰段融合术在2年时显示出更低的成本,并改善了QALY增益,且与上胸椎融合术相比,再手术率和住院时间并未增加。
III级