• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于小儿实体瘤研究的临床前模型：聚焦骨肉瘤

Preclinical models for the study of pediatric solid tumors: focus on bone sarcomas.

作者信息

Petrescu D Isabel, Yustein Jason T, Dasgupta Atreyi

机构信息

Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA, United States.

The Faris D. Virani Ewing Sarcoma Center, Baylor College of Medicine, Texas Children's Cancer and Hematology Centers, Houston, TX, United States.

出版信息

Front Oncol. 2024 Jul 18;14:1388484. doi: 10.3389/fonc.2024.1388484. eCollection 2024.

DOI:10.3389/fonc.2024.1388484
PMID:39091911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11291195/
Abstract

Sarcomas comprise between 10-15% of all pediatric malignancies. Osteosarcoma and Ewing sarcoma are the two most common pediatric bone tumors diagnosed in children and young adults. These tumors are commonly treated with surgery and/or radiation therapy and combination chemotherapy. However, there is a strong need for the development and utilization of targeted therapeutic methods to improve patient outcomes. Towards accomplishing this goal, pre-clinical models for these unique malignancies are of particular importance to design and test experimental therapeutic strategies prior to being introduced to patients due to their origination site and propensity to metastasize. Pre-clinical models offer several advantages for the study of pediatric sarcomas with unique benefits and shortcomings dependent on the type of model. This review addresses the types of pre-clinical models available for the study of pediatric solid tumors, with special attention to the bone sarcomas osteosarcoma and Ewing sarcoma.

摘要

肉瘤占所有儿童恶性肿瘤的10%-15%。骨肉瘤和尤文肉瘤是儿童和青年中诊断出的两种最常见的儿童骨肿瘤。这些肿瘤通常采用手术和/或放射治疗以及联合化疗进行治疗。然而，迫切需要开发和利用靶向治疗方法来改善患者预后。为了实现这一目标，由于这些独特恶性肿瘤的起源部位和转移倾向，在将实验性治疗策略引入患者之前，针对这些肿瘤的临床前模型对于设计和测试实验性治疗策略尤为重要。临床前模型为儿童肉瘤的研究提供了几个优点，其独特的优点和缺点取决于模型的类型。本综述探讨了可用于研究儿童实体瘤的临床前模型类型，特别关注骨肉瘤和尤文肉瘤这两种骨肉瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e34/11291195/edbedfcf9cef/fonc-14-1388484-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e34/11291195/5dd482a11f97/fonc-14-1388484-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e34/11291195/4393b794588e/fonc-14-1388484-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e34/11291195/edbedfcf9cef/fonc-14-1388484-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e34/11291195/5dd482a11f97/fonc-14-1388484-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e34/11291195/4393b794588e/fonc-14-1388484-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e34/11291195/edbedfcf9cef/fonc-14-1388484-g003.jpg

相似文献

1
Preclinical models for the study of pediatric solid tumors: focus on bone sarcomas.用于小儿实体瘤研究的临床前模型：聚焦骨肉瘤
Front Oncol. 2024 Jul 18;14:1388484. doi: 10.3389/fonc.2024.1388484. eCollection 2024.
2
Prospects and Advances in Adoptive Natural Killer Cell Therapy for Unmet Therapeutic Needs in Pediatric Bone Sarcomas.过继性自然杀伤细胞疗法在儿科骨肿瘤未满足的治疗需求方面的前景与进展。
Int J Mol Sci. 2023 May 5;24(9):8324. doi: 10.3390/ijms24098324.
3
Challenges of Systemic Therapy Investigations for Bone Sarcomas.骨肉瘤系统治疗研究的挑战。
Int J Mol Sci. 2022 Mar 24;23(7):3540. doi: 10.3390/ijms23073540.
4
Advances in the Treatment of Pediatric Bone Sarcomas.小儿骨肉瘤治疗进展
Am Soc Clin Oncol Educ Book. 2017;37:725-735. doi: 10.1200/EDBK_175378.
5
Xenograft and genetically engineered mouse model systems of osteosarcoma and Ewing's sarcoma: tumor models for cancer drug discovery.骨肉瘤和尤文肉瘤的异种移植和基因工程小鼠模型系统：癌症药物发现的肿瘤模型。
Expert Opin Drug Discov. 2013 Oct;8(10):1181-9. doi: 10.1517/17460441.2013.817988. Epub 2013 Jul 12.
6
Bone sarcomas of the head and neck in children: the St Jude Children's Research Hospital experience.儿童头颈部骨肉瘤：圣裘德儿童研究医院的经验
Cancer. 2000 May 1;88(9):2172-80. doi: 10.1002/(sici)1097-0142(20000501)88:9<2172::aid-cncr25>3.0.co;2-7.
7
The value of adjuvant chemotherapy in the management of sarcomas in children.辅助化疗在儿童肉瘤治疗中的价值。
Cancer. 1985 May 1;55(9 Suppl):2184-97. doi: 10.1002/1097-0142(19850501)55:9+<2184::aid-cncr2820551422>3.0.co;2-n.
8
The 'other' bone sarcomas in Japan: a retrospective study of primary bone sarcomas other than osteosarcoma, Ewing sarcoma and chondrosarcoma, using data from the Bone Tumuor Registry in Japan.日本的“其他”骨肉瘤：一项对骨肉瘤、尤因肉瘤和软骨肉瘤以外的原发性骨肉瘤的回顾性研究，使用来自日本骨肿瘤登记处的数据。
Jpn J Clin Oncol. 2021 Aug 30;51(9):1430-1436. doi: 10.1093/jjco/hyab090.
9
Is Surgical Resection of the Primary Site Associated with an Improved Overall Survival for Patients with Primary Malignant Bone Tumors Who Have Metastatic Disease at Presentation?对于初诊时即发生转移的原发性骨恶性肿瘤患者，外科切除原发灶是否能提高总生存率？
Clin Orthop Relat Res. 2020 Oct;478(10):2284-2295. doi: 10.1097/CORR.0000000000001361.
10
Bisphosphonates in common pediatric and adult bone sarcomas.常见儿科和成人骨肉瘤中的双膦酸盐。
Bone. 2020 Oct;139:115523. doi: 10.1016/j.bone.2020.115523. Epub 2020 Jul 3.

引用本文的文献

1
Molecular and Glycosylation Pathways in Osteosarcoma: Tumor Microenvironment and Emerging Strategies Toward Personalized Oncology.骨肉瘤中的分子和糖基化途径：肿瘤微环境与个性化肿瘤学的新兴策略
Curr Issues Mol Biol. 2025 Aug 7;47(8):629. doi: 10.3390/cimb47080629.
2
3D-printed β-TCP scaffold as a bone-mimicking environment for an engineered model of osteosarcoma: properties and transcriptomic insights.3D打印β-磷酸三钙支架作为骨肉瘤工程模型的骨模拟环境：特性与转录组学见解
Mater Today Bio. 2025 Apr 12;32:101766. doi: 10.1016/j.mtbio.2025.101766. eCollection 2025 Jun.

本文引用的文献

1
An osteosarcoma-on-a-chip model for studying osteosarcoma matrix-cell interactions and drug responses.一种用于研究骨肉瘤基质-细胞相互作用和药物反应的芯片上骨肉瘤模型。
Bioact Mater. 2023 Dec 14;34:1-16. doi: 10.1016/j.bioactmat.2023.12.005. eCollection 2024 Apr.
2
A humanized orthotopic mouse model for preclinical evaluation of immunotherapy in Ewing sarcoma.用于尤文肉瘤免疫治疗临床前评估的人源化原位小鼠模型。
Front Immunol. 2023 Oct 6;14:1277987. doi: 10.3389/fimmu.2023.1277987. eCollection 2023.
3
Ewing sarcoma from molecular biology to the clinic.
尤因肉瘤：从分子生物学到临床应用
Front Cell Dev Biol. 2023 Sep 11;11:1248753. doi: 10.3389/fcell.2023.1248753. eCollection 2023.
4
Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans.犬骨肉瘤的转录组分析确定了具有人类转化价值的预后基因表达特征。
Commun Biol. 2023 Aug 17;6(1):856. doi: 10.1038/s42003-023-05208-z.
5
MYC regulates CSF1 expression via microRNA 17/20a to modulate tumor-associated macrophages in osteosarcoma.MYC 通过 microRNA 17/20a 调控 CSF1 的表达，从而调节骨肉瘤中的肿瘤相关巨噬细胞。
JCI Insight. 2023 Jul 10;8(13):e164947. doi: 10.1172/jci.insight.164947.
6
Clinical Targeted Next-Generation Panel Sequencing Reveals Amplification Is a Poor Prognostic Factor in Osteosarcoma.临床靶向下一代基因测序panel 揭示骨肉瘤中扩增是一个不良预后因素。
JCO Precis Oncol. 2023 Mar;7:e2200334. doi: 10.1200/PO.22.00334.
7
Modeling Ewing Sarcoma Lung Metastasis.建模尤文肉瘤肺转移。
Curr Protoc. 2023 Feb;3(2):e670. doi: 10.1002/cpz1.670.
8
Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis.人类EWS-FLI蛋白在果蝇中重现了诱导尤因肉瘤肿瘤发生的新功能。
PNAS Nexus. 2022 Oct 6;1(4):pgac222. doi: 10.1093/pnasnexus/pgac222. eCollection 2022 Sep.
9
Cancer statistics, 2023.癌症统计数据，2023 年。
CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763.
10
Osteosarcoma.骨肉瘤。
Nat Rev Dis Primers. 2022 Dec 8;8(1):77. doi: 10.1038/s41572-022-00409-y.