Kacar Emine, Oz Zeynep Dila, Serhatlioglu Ihsan, Kaya Tektemur Nalan, Ozdede Mehmet Ridvan, Yalcin Tugce, Ozbeg Gulendam, Ozgen Aslisah, Tan Fatih, Orhan Seval Ulku, Zorlu Ozge, Ucer Aysun, Yasar Abdullah, Yilmaz Bayram, Kelestimur Haluk
Department of Physiology, Firat University, Elazig, Turkey.
Department of Biophysics, Firat University, Elazig, Turkey.
Arch Physiol Biochem. 2025 Feb;131(1):24-32. doi: 10.1080/13813455.2024.2386279. Epub 2024 Aug 2.
To investigate the comprehensive effects of daily chronic asprosin administration on various pubertal and reproductive parameters in female rats. This study aims to elucidate the role of asprosin in regulating the onset of puberty and its influence on hormonal profiles and ovarian histology.
Asprosin was administered intraperitoneally (i.p.) at a dose of 500 ng/kg daily for eight weeks. Hormonal assays and histological analyses were performed to evaluate the effects of asprosin on the onset of puberty and reproductive function.
Daily chronic administration of asprosin accelerated the onset of the first oestrus. Hormonal assays revealed significant elevations in serum levels of Follicle-Stimulating Hormone (FSH) and Oestradiol (E2), while Inhibin B levels decreased. Histological evaluations demonstrated an increased number of primary and secondary follicles in ovarian tissue, without affecting primordial follicle counts or reproductive organ weights.
Role of adipokines in regulating puberty and reproductive function has increasingly gained recognition. This study aimed to provide the first comprehensive examination of the effects of daily chronic asprosin administration on pubertal and reproductive parameters in female rats. Utilising hormonal assays and histological analyses, asprosin was administered intraperitoneally (i.p.) at a dose of 500 ng/kg, daily, for eight weeks. Our findings revealed that daily chronic administration of asprosin accelerated the onset of the first oestrus. Hormonal assays showed significant elevations in serum levels of Follicle-Stimulating Hormone (FSH) and Oestradiol (E2), while Inhibin B levels decreased. Histological evaluations demonstrated an increased number of primary and secondary follicles in ovarian tissue, without affecting primordial follicle counts or reproductive organ weights. These results provide new insights into asprosin's role in advancing the age of first oestrus and modulating hormonal profiles, thereby offering potential benefits to the female reproductive system.
研究每日慢性给予阿朴脂蛋白对雌性大鼠各种青春期和生殖参数的综合影响。本研究旨在阐明阿朴脂蛋白在调节青春期启动中的作用及其对激素水平和卵巢组织学的影响。
以500 ng/kg的剂量每日腹腔注射阿朴脂蛋白，持续八周。进行激素检测和组织学分析，以评估阿朴脂蛋白对青春期启动和生殖功能的影响。
每日慢性给予阿朴脂蛋白加速了首次发情的启动。激素检测显示促卵泡生成素（FSH）和雌二醇（E2）血清水平显著升高，而抑制素B水平降低。组织学评估表明卵巢组织中初级和次级卵泡数量增加，而原始卵泡数量和生殖器官重量不受影响。
脂肪因子在调节青春期和生殖功能中的作用越来越受到认可。本研究旨在首次全面考察每日慢性给予阿朴脂蛋白对雌性大鼠青春期和生殖参数的影响。利用激素检测和组织学分析，以500 ng/kg的剂量每日腹腔注射阿朴脂蛋白，持续八周。我们的研究结果显示，每日慢性给予阿朴脂蛋白加速了首次发情的启动。激素检测显示促卵泡生成素（FSH）和雌二醇（E2）血清水平显著升高，而抑制素B水平降低。组织学评估表明卵巢组织中初级和次级卵泡数量增加，而原始卵泡数量和生殖器官重量不受影响。这些结果为阿朴脂蛋白在提前首次发情年龄和调节激素水平方面的作用提供了新的见解，从而为雌性生殖系统带来潜在益处。
