Health Science University, Ankara, Turkey.
Andes Pediatr. 2024 Jun;95(3):244-251. doi: 10.32641/andespediatr.v95i3.4720. Epub 2024 Mar 13.
Some systemic inflammatory indices have been reported to be associated with intracerebral hemorrhage in adults. However, the relationship between systemic inflammatory indices and intraventricular hemorrhage (IVH) in premature neonates is still not completely understood.
To evaluate the relationship between systemic inflammatory indices obtained on the first day of life in premature infants and the development of severe IVH.
Premature newborns < 32 weeks of gestational age were included. Eligible patients were divided into 2 groups: Group 1: without IVH or grade I and II hemorrhage, and Group 2: grade III and IV HIV. Demographic characteristics, clinical outcomes, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), pan-immune inflammation value (PIV), and Systemic inflammation response index (SIRI) were compared between groups.
A total of 1176 newborns were included in the study, 1074 in Group 1 and 102 premature babies in Group 2. There was no difference between the groups in terms of the count of leukocytes, neutrophils, monocytes, lymphocytes and platelets (p > 0.05). The values of NLR, MLR, PLR, PIV, SII and SIRI were similar in both groups (p > 0.05).
While the relationship between inflammation, hemodynamics and IVH is still under discussion, our results show that systemic inflammatory indices have no predictive value for IVH.
评估早产儿出生第 1 天的全身炎症指标与严重脑室出血（IVH）发展之间的关系。
纳入胎龄<32 周的早产儿。符合条件的患者分为 2 组：组 1：无 IVH 或 1 级和 2 级出血，组 2：3 级和 4 级 HIV。比较两组之间的人口统计学特征、临床结局、单核细胞与淋巴细胞比值（MLR）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、全身免疫炎症指数（SII）、泛免疫炎症值（PIV）和全身炎症反应指数（SIRI）。
共有 1176 名新生儿纳入研究，其中 1074 名在组 1，102 名早产儿在组 2。两组白细胞、中性粒细胞、单核细胞、淋巴细胞和血小板计数无差异（p>0.05）。两组 NLR、MLR、PLR、PIV、SII 和 SIRI 相似（p>0.05）。
虽然炎症、血液动力学和 IVH 之间的关系仍在讨论中，但我们的结果表明全身炎症指标对 IVH 无预测价值。
