Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, PRC.
Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, PRC.
Clinics (Sao Paulo). 2024 Aug 2;79:100462. doi: 10.1016/j.clinsp.2024.100462. eCollection 2024.
The authors aim to investigate the effect of music on hemodynamic fluctuations during induction of general anesthesia and reducing preoperative anxiety for women who underwent elective non-cardiac surgery.
It is a multicenter, double-blind, randomized, parallel-group clinical trial. Patients were randomized 1:1 to either a Music Intervention group (MI) or a Control group (Control). The MI participants listened to their preferred music for more than 30 minutes in the waiting area. The State-Trait Anxiety Inventory (STAI) was used to measure anxiety levels in the groups, and hemodynamic parameters (Heart Rate [HR], Mean Arterial Pressure [MAP]) were continuously recorded before induction (T0), at loss of consciousness (T1), immediately before intubation (T2), and after intubation (T3). Intubation-related adverse events were also recorded. The primary outcome was the incidence of MAP changes more than 20 % above baseline during T0-T2.
A total of 164 patients were included in the final analyses. The incidence of MAP instability during T0-T2 was lower in the MI, and the 95 % Confidence Interval for the rate difference demonstrated the superiority of MI. HR instability was less frequent in MI participants both in T0-T2 and T2-T3. The overall incidence of preoperative anxiety was 53.7 % (88/164). After the music intervention, the mean score of STAI was significantly lower in the MI than in the Control, with a between-group difference of 8.01.
Preoperative music intervention effectively prevented hemodynamic instability during anesthesia induction and significantly reduced preoperative anxiety in women undergoing elective non-cardiac surgery.
本研究旨在探讨诱导全身麻醉期间音乐对血流动力学波动的影响，以及减轻择期非心脏手术女性患者术前焦虑。
这是一项多中心、双盲、随机、平行组临床试验。患者按 1:1 随机分为音乐干预组（MI）或对照组（Control）。MI 组患者在等候区听他们喜欢的音乐超过 30 分钟。采用状态-特质焦虑量表（STAI）评估两组焦虑水平，连续记录诱导前（T0）、意识丧失时（T1）、插管前即刻（T2）和插管后（T3）的血流动力学参数（心率[HR]、平均动脉压[MAP]）。还记录了与插管相关的不良事件。主要结局是 T0-T2 期间 MAP 变化超过基线 20%的发生率。
共有 164 例患者纳入最终分析。MI 组 T0-T2 期间 MAP 不稳定的发生率较低，且率差的 95%置信区间表明 MI 具有优势。MI 组患者在 T0-T2 和 T2-T3 期间 HR 不稳定的发生率均较低。术前焦虑的总发生率为 53.7%（88/164）。音乐干预后，MI 组 STAI 评分明显低于对照组，组间差异为 8.01。
术前音乐干预可有效预防麻醉诱导期间血流动力学不稳定，并显著降低择期非心脏手术女性患者的术前焦虑。
