伊朗 HIV 感染者中乙型肝炎、丙型肝炎和结核病的流行情况：系统评价和荟萃分析。

Prevalence of hepatitis B, hepatitis C, and tuberculosis among people living with HIV in Iran: a systematic review and meta-analysis.

机构信息

Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.

Department of Epidemiology, School of Public Health, Hamadan University of Medical Science, Hamadan, Iran.

出版信息

BMC Infect Dis. 2024 Aug 3;24(1):777. doi: 10.1186/s12879-024-09676-4.

DOI:10.1186/s12879-024-09676-4

PMID:39097724

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11297631/

Abstract

BACKGROUND

Up to now several studies estimate the prevalence of HBV, HCV, and TB among people living with HIV (PLWH) in Iran; however, their results are inconsistent. This study aimed to estimate the overall prevalence of HBV, HVC, and TB among Iranian PLWH.

METHODS

In this systematic review and meta-analysis six databases including Medline, Web of Science, Scopus, MagIran, Scientific Information Database (SID), and Barakat Knowledge network system were searched up to October 2023 with no language restriction. All studies estimated the prevalence of HBV, HCV, and TB among PLWH in Iran were included. The random-effects model was used to report the study estimates. Results were reported at a 95% confidence interval (CI).

RESULTS

Out of 1050 retrieved references, 58 articles met the eligibility criteria. Overall among PLWH, HBV prevalence was 13.0% (95% CI: 11.0, 15.0), HCV prevalence was 54% (95% CI: 45.0, 64.0), and TB prevalence was 19% (95% CI: 13.0, 24.0). The results from multivariate meta-regression analysis showed no statistically significant association between HBV and TB prevalence with the year of study, quality of studies, age, gender, and persons who inject drugs (PWID). HCV prevalence was significantly associated with PWID.

CONCLUSION

We found HBV, HCV, and TB infections are common among PLWH in Iran and required to be screened and treated with effective and timely services.

摘要

背景

迄今为止，已有多项研究估计了伊朗 HIV 感染者（PLWH）中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和结核病（TB）的流行率；然而，这些结果并不一致。本研究旨在估计伊朗 PLWH 中 HBV、HCV 和 TB 的总体流行率。

方法

本系统评价和荟萃分析共检索了 6 个数据库，包括 Medline、Web of Science、Scopus、MagIran、Scientific Information Database（SID）和 Barakat Knowledge network system，截至 2023 年 10 月，无语言限制。所有研究均估计了伊朗 PLWH 中 HBV、HCV 和 TB 的流行率。采用随机效应模型报告研究估计值。结果以 95%置信区间（CI）报告。

结果

从 1050 篇检索文献中，有 58 篇文章符合纳入标准。总体而言，PLWH 中 HBV 流行率为 13.0%（95%CI：11.0，15.0），HCV 流行率为 54%（95%CI：45.0，64.0），TB 流行率为 19%（95%CI：13.0，24.0）。多变量荟萃回归分析结果表明，HBV 和 TB 流行率与研究年份、研究质量、年龄、性别和注射毒品者（PWID）之间无统计学显著关联。HCV 流行率与 PWID 显著相关。